TNK1 Antibody (YA5084)
(Synonyms: TNK1; Non-receptor tyrosine-protein kinase TNK1; CD38 negative kinase 1)TNK1 Antibody (YA5084) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to TNK1.
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Host:
Mouse
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Application:
WB, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|
| Dilution Ratio | 1:500-1:2000 | 1:10000 |
Product Details
TNK1 Antibody (YA5084) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to TNK1.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 72 kDa;
Purified recombinant fragment of TNK1 (aa451-560) expressed in E. Coli.
affinity purified.
Non-conjugated
Unmodified
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
TNK1 is involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in human tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction
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Subcellular Localization
Cytoplasm; Membrane; Peripheral membrane protein
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Expression
Tissue_specificity:Expressed in all umbilical cord blood, bone marrow and human blood cell sub-populations and in several leukemia cell lines. Highly expressed in fetal blood, brain, lung, liver and kidney. Detected at lower levels in human prostate, testis, ovary, small intestine and colon. Not expressed in human lung, liver, kidney or brain -
Isoforms & Post-Translational Modification
Q13470 has 2 isomers: Q13470-1: 72468 Da (predicted); Q13470-2: 71922 Da (predicted).
Autophosphorylated on tyrosine residues -
Subunit
Interacts with the SH3 domain of PLCG1 via its Pro-rich domain
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SwissProt ID
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Synonyms
TNK1; Non-receptor tyrosine-protein kinase TNK1; CD38 negative kinase 1
Documentation
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