country

Change Language

Country or Region:

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-P87760

TRF1 Antibody (YA7445)

TRF1 Antibody (YA7445) is a Rabbit-derived and non-conjugated IgG, Kappa monoclonal antibody, targeting to TRF1.

For research use only. We do not sell to patients.

Formulation:
Supplied in PBS (pH7.4) containing 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Applications

Application	WB WB: Western Blot	ICC/IF ICC/IF: Immunocytochemistry/ Immunofluorescence	ELISA ELISA: Enzyme Linked Immunosorbent Assay
Dilution Ratio	1:1000-1:5000	1:200-1:1000	1:5000-1:20000

Description

TRF1 Antibody (YA7445) is a Rabbit-derived and non-conjugated IgG, Kappa monoclonal antibody, targeting to TRF1.

Host Rabbit
Clonality Monoclonal,Recombinant
Species Reactivity
Human, Mouse
Observed Molecular Weight

Observed band size: 60 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Calculated Molecular Weight Predicted band size: 50 kDa

Immunogen

The exact sequence is proprietary to MCE.

Sensitivity

Endogenous

Purification

Protein A affinity purified

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG, Kappa

Appearance

Liquid
Formulation

Supplied in PBS (pH7.4) containing 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.

Function

TRF1 binds the telomeric double-stranded 5'-TTAGGG-3' repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways
Subcellular Localization

Nucleus,Cytoplasm, cytoskeleton, spindle,Chromosome, telomere
Expression

Tissue_Specificity: Highly expressed and ubiquitous. Isoform Pin2 predominates
Induction: Expression is tightly regulated during the cell cycle; levels are low in G1 and S phase and increase during G2 phase and mitosis
Isoforms & Post-Translational Modification

P54274 has two isomers: P54274-1: 50246 Da (predicted); P54274-2: 48239 Da (predicted).
Phosphorylated preferentially on Ser-219 in an ATM-dependent manner in response to ionizing DNA damage丨ADP-ribosylation by TNKS1 or TNKS2 diminishes its ability to bind to telomeric DNA丨Ubiquitinated by RLIM/RNF12, leading to its degradation by the proteasome
Subunit

Homodimer; can contain both isoforms
SwissProt ID

P54274