TRIM22 Antibody (YA8595)
(Synonyms: GPSTAF50; RNF94; STAF50)TRIM22 Antibody (YA8595) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TRIM22.
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Host:
Mouse
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Isotype:
IgG1
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Application:
IHC-P, ICC/IF
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Reactivity :
Human
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|
| Dilution Ratio | 1:150-500 | 1:100-250 |
Product Details
TRIM22 Antibody (YA8595) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TRIM22.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 56.8 kDa
Human recombinant protein fragment corresponding to amino acids 61-406 of human TRIM22 produced in E.coli.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
TRIM22 is an Interferon-induced E3 ubiquitin ligase that plays important roles in innate and adaptive immunity. Restricts the replication of many viruses including HIV-1, encephalomyocarditis virus (EMCV), hepatitis B virus (HBV), hepatitis C virus (HCV) or Zika virus (ZIKV). Mechanistically, negatively regulates HCV replication by promoting ubiquitination and subsequent degradation of viral NS5A. Also acts by promoting the degradation of Zika virus NS1 and NS3 proteins through proteasomal degradation. Acts as a suppressor of basal HIV-1 LTR-driven transcription by preventing Sp1 binding to the HIV-1 promoter. Also plays a role in antiviral immunity by co-regulating together with NT5C2 the RIGI/NF-kappa-B pathway by promoting 'Lys-63'-linked ubiquitination of RIGI, while NT5C2 is responsible for 'Lys-48'-linked ubiquitination of RIGI. Participates in adaptive immunity by suppressing the amount of MHC class II protein in a negative feedback manner in order to limit the extent of MHC class II induction[1][2][3][4][5].
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Subcellular Localization
Cytoplasm,Nucleus,Nucleus speckle,Nucleus, Cajal body
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Expression
Tissue_Specificity: Strongly expressed in peripheral blood leukocytes, spleen, thymus, and ovary. Expressed at basal levels in other tissues
Induction: By interferons alpha and beta (PubMed:25683609). Up-regulated by p53/TP53. Dramatically induced by progesterone in MDA-MB-231-derived ABC28 cells and T47D cells. By interferon gamma (PubMed:35777501). Expression is also modulated in response to several viruses and viral antigens (PubMed:36042495) -
Isoforms & Post-Translational Modification
Q8IYM9 has two isomers: Q8IYM9-1: 56947 Da (predicted); Q8IYM9-2: 56429 Da (predicted).
Auto-ubiquitinated -
Subunit
Homotrimer (PubMed:17156811)
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SwissProt ID
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Synonyms
GPSTAF50; RNF94; STAF50
Documentation
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