TRIM23 Antibody (YA2269)

製品番号: HY-P82524: データシート User Guide for Antibodies
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TRIM23 Antibody (YA2269) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TRIM23.

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容量	価格（税別）	在庫状況	数量
20 μL	$146	Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
50 μL	$222	Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
100 μL	$360	Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
250 μL		お問い合わせ

Synthetic products have potential research and development risk.

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* アイテムを追加する前、数量をご選択ください

おすすめ:

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
説明

製品説明

TRIM23 Antibody (YA2269) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TRIM23.

Host

Rabbit

Clonality

Recombinant, Monoclonal

分子量

Predicted band size: 64 kDa;

Observed band size: 64 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Mouse, Rat

SwissProt ID

P36406

Gene ID

373 [NCBI]

Immunogen

A synthetic peptide of human TRIM23

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-1:1000

Sensitivity	Endogenous	純度	Affinity Purified
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

輸送条件

Shipping with blue ice.

Background

Function：Acts as an E3 ubiquitin-protein ligase. Plays an essential role in autophagy activation during viral infection. Mechanistically, activates TANK-binding kinase 1/TBK1 by facilitating its dimerization and ability to phosphorylate the selective autophagy receptor SQSTM1. In order to achieve this function, TRIM23 mediates 'Lys-27'-linked auto-ubiquitination of its ADP-ribosylation factor (ARF) domain to induce its GTPase activity and its recruitment to autophagosomes (PubMed:28871090); (Microbial infection) Mediates TRAF6 auto-ubiquitination in the presence of human cytomegalovirus protein UL144, resulting in the virally controlled activation of NF-kappa-B stimulation at early times of HCMV infection

Subcellular Localization：Cytoplasm; Endomembrane system; Golgi apparatus membrane; Lysosome membrane

Isoforms & Post-Translational Modification：P36406 has 3 isomers: P36406-1: 64067 Da (predicted); P36406-2: 63690 Da (predicted); P36406-3: 61068 Da (predicted).

Subunit：Homodimer. Interacts with PSCD1. Interacts with UBE2D2 (PubMed:28681414). Interacts with TBK1 (via N-terminal kinase domain) and p62/SQSTM1

Database

Entrez Gene: 373 Human ; 81003 Mouse ; 81002 Rat

SwissProt: P36406 Human ; Q8BGX0 Mouse ; P36407 Rat

OMIM: 601747 Human

Research Field

Signal Transduction

Synonyms

ARD1; ARFD1; RNF46

ドキュメンテーション

User Guide for Antibodies (1077 KB)