TSC22D3 Antibody (YA8097)(PBS only)

Cat. No.: HY-P88413A: Data Sheet User Guide for Antibodies
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TSC22D3 Antibody (YA8097) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to TSC22D3.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

TSC22D3 Antibody (YA8097) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to TSC22D3.

Host

Mouse

Molecular Weight

Predicted band size: 14.6 kDa

Species Reactivity

Human, Mouse

SwissProt ID

Q99576

Immunogen

Full length human recombinant protein of human TSC22D3 produced in HEK293T cell.

Application &
Dilution Ratio

Application	Dilution Ratio
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:100-250

Purity	Affinity purified	Conjugation	Non-conjugated
Isotype	IgG2b

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11 (PubMed:15031210). In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10 (PubMed:12393603). In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation and thereby NFKB1 DNA-binding activities (PubMed:11468175). In vitro, suppresses AP-1 transcription factor complex DNA-binding activities (By similarity)|Inhibits myogenic differentiation and mediates anti-myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG

Subcellular Localization：Cytoplasm,Nucleus

Expression：
Tissue_Specificity: Ubiquitously expressed, including in the fetal brain and liver (PubMed:26752201). Expressed in brain, lung, spleen and skeletal muscle (PubMed:11313722, PubMed:12393603). Lower levels detected in heart and kidney (PubMed:11313722, PubMed:12393603). Not detected in the pancreas (PubMed:11313722). In non-lymphoid tissues, in the absence of inflammation, the major source of constitutive expression is the macrophage lineage (PubMed:12393603). Also expressed in cells from different hemopoietic cell lineages, including bone marrow cells, CD34+ stem cells, mature B- and T-cells, monocytes and granulocytes (PubMed:11313722). Down-regulated in activated macrophages from inflammatory lesions of delayed-type hypersensitivity (DTH) reactions, such as in tuberculosis and in Crohn disease, whereas in Burkitt lymphoma, persists in macrophages involved in the phagocytosis of apoptotic malignant cells (PubMed:12393603)
Induction: Induced in T-lymphocytes by IL2 deprivation

Isoforms & Post-Translational Modification：Q99576 has three isomers: Q99576-1: 14810 Da (predicted); Q99576-3: 22213 Da (predicted); Q99576-5: 8673 Da (predicted).

Subunit：Can form homodimers, however it is likely to function as a monomer (By similarity)

Synonyms

DIP; DSIPI; GILZ; TSC-22R

Documentation

User Guide for Antibodies (1077 KB)