2. Antibodies
  3. Primary Antibodies
  4. Monoclonal Antibodies Recombinant Antibodies
  5. TXNIP Antibody (YA7422)

TXNIP Antibody (YA7422) is a Rabbit-derived and non-conjugated IgG, Kappa monoclonal antibody, targeting to TXNIP.

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容量 価格（税別） 在庫状況 数量
20 μL $135 在庫あり
50 μL $215 在庫あり
100 μL $340 在庫あり
250 μL   お問い合わせ  
or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • 説明

製品説明

TXNIP Antibody (YA7422) is a Rabbit-derived and non-conjugated IgG, Kappa monoclonal antibody, targeting to TXNIP.
Host

Rabbit
Clonality

Monoclonal,Recombinant
分子量
Predicted band size: 44 kDa;
Observed band size: 55 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human, Mouse, Rat
SwissProt ID
Immunogen

The exact sequence is proprietary to MCE.
Application &
Dilution Ratio
Application Dilution Ratio
IHC-P
IHC-P: Immunohistochemistry-Paraffin
1:200-1:1000
WB
WB: Western Blot
1:1000-1:5000
ICC/IF
ICC/IF: Immunocytochemistry/Immunofluorescence
1:200-1:1000
ELISA
ELISA: Enzyme Linked Immunosorbent Assay
1:5000-1:20000
Sensitivity Endogenous 純度 Protein A affinity purified
Conjugation Non-conjugated Modification Unmodified
Isotype IgG,Kappa  
Appearance

Liquid
Formulation

Supplied in PBS (pH7.4) containing 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
輸送条件

Shipping with blue ice.
Background
Function：May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability (PubMed:17603038). Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm (By similarity). Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest (PubMed:12821938). Required for the maturation of natural killer cells (By similarity). Acts as a suppressor of tumor cell growth (PubMed:18541147). Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1) (PubMed:21460850)
Subcellular Localization：Cytoplasm,Nucleus
Expression：Induction: By 1,25-dihydroxyvitamin D-3 and TGFB1. Down-regulated in response to oxidative stress
Isoforms & Post-Translational Modification：Q9H3M7 has two isomers: Q9H3M7-1: 43661 Da (predicted); Q9H3M7-2: 37319 Da (predicted).
Ubiquitinated; undergoes heterotypic 'Lys-48'-/'Lys-63'-branched polyubiquitination catalyzed by ITCH and UBR5 resulting in proteasomal degradation (PubMed:29378950)
Subunit：Homodimer; disulfide-linked (PubMed:23519408)
ドキュメンテーション
User Guide for Antibodies (1077 KB)

TXNIP Antibody (YA7422) 関連分類

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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製品名:
TXNIP Antibody (YA7422)
製品番号:
HY-P87737
数量:
MCE 日本正規代理店:

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