Tyrosinase Antibody (YA5658)
(Synonyms: ATN; CMM8; LB24 AB; LB24-AB; Monophenol monooxygenase; OCA1; OCA1A; OCAIA; Oculocutaneous albinism IA; SHEP3; SK29 AB; SK29-AB; Tumor rejection antigen AB; TYR; TYRO_HUMAN; tyrosinase; oculocutaneous albinism IA; Tyrosinase)Tyrosinase Antibody (YA5658) is a Mouse-derived and non-conjugated IgA monoclonal antibody, targeting to Tyrosinase.
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Host:
Mouse
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Isotype:
IgA
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Application:
IHC-P, WB, ICC/IF, ELISA
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Reactivity :
Human, Mouse,
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Formulation:
Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|---|
| Dilution Ratio | 1:200-1000 | 1:500-2000 | 1:100-500 | 1:1000-5000 |
Product Details
Tyrosinase Antibody (YA5658) is a Mouse-derived and non-conjugated IgA monoclonal antibody, targeting to Tyrosinase.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse,
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Observed Molecular WeightObserved band size: 50-80 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 60 kDa
Synthesized peptide derived from human Tyrosinase AA range: 250-350
Protein G
Non-conjugated
Unmodified
IgA
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Tyrosinase is a copper-containing metalloprotein belonging to the type-3 copper protein family, together with haemocyanins and catechol oxidases. Tyrosinases are the catalysts in mammals responsible for the formation of melanin in skin and hair color, as well as browning in fruit and vegetables following cell damage.
Tyrosinases are found in various prokaryotes as well as in plants, fungi, arthropods, and mammals and are responsible for pigmentation, wound healing, radiation protection, and primary immune response. Tyrosinases perform two sequential enzymatic reactions: hydroxylation of monophenols and oxidation of diphenols to form quinones which polymerize spontaneously to melanin. In plants, sponges, and many invertebrates, tyrosinases are important for wound healing and primary immune responses; in arthropods, they play a role in sclerotization, and in bacteria, tyrosinases protect DNA from UV damage.
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Subcellular Localization
Melanosome membrane; Single-pass type I membrane protein; Melanosome
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Expression
Induction:Increased expression after UVB irradiation -
Isoforms & Post-Translational Modification
P14679 has 2 isomers: P14679-1: 60393 Da (predicted); P14679-2: 42914 Da (predicted).
Glycosylated -
Subunit
Forms an OPN3-dependent complex with DCT in response to blue light in melanocytes
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SwissProt ID
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Synonyms
ATN; CMM8; LB24 AB; LB24-AB; Monophenol monooxygenase; OCA1; OCA1A; OCAIA; Oculocutaneous albinism IA; SHEP3; SK29 AB; SK29-AB; Tumor rejection antigen AB; TYR; TYRO_HUMAN; tyrosinase; oculocutaneous albinism IA; Tyrosinase
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