2. Apoptosis
  3. Apoptosis
  4. Anticancer agent 195

Anticancer agent 195 (Compound 10) is an inhibitor for ELF3-MED23 PPI with Ki of 0.68 μM. Anticancer agent 195 induces apoptosis and exhibits antitumor activity.

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Anticancer agent 195

Anticancer agent 195 Estructura química

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Anticancer agent 195 Related Antibodies

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Descripciòn

Anticancer agent 195 (Compound 10) is an inhibitor for ELF3-MED23 PPI with Ki of 0.68 μM. Anticancer agent 195 induces apoptosis and exhibits antitumor activity[1].

IC50 & Target

>Ki: 0.68 μM (ELF3-MED23 PPI)
In Vitro

Anticancer agent 195 (10 μM) blocks the ELF3-MED23 interaction, inhibits activity of HER2 promoter and followed phosphorylation of AKT and MAPK[1].
Anticancer agent 195 (10 μM) reveals an anti-proliferative and apoptotic-inducing efficacy in cells NCI-N87, exhibits potency against trastuzumab resistance[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anticancer agent 195 Related Antibodies

Western Blot Analysis[1]

Cell Line: NCI-N87, NCI-N87 TR
Concentration: 0-10 μM
Incubation Time: 16 h
Result: Reduced levels of HER2, phosphorylated AKT and p-MAPK.
Increased cleaved PARP and c-caspase 3.

Apoptosis Analysis[1]

Cell Line: NCI-N87, NCI-N87 TR
Concentration: 0-15 μM
Incubation Time: 24 h
Result: Induced apoptosis in a dose-dependent manner.
In Vivo

Anticancer agent 195 (4 mg/kg, i.v. for 25 days) inhibited tumor growth in NCI-N87 xenograft athymic nude mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NCI-N87 xenograft athymic nude mice[1]
Dosage: 4 mg/kg
Administration: i.v., every three days for 25 days
Result: Inhibited tumor growth.
Peso molecular

412.48

Fòrmula

C24H28O6
SMILES

COC1=CC(C(/C=C/C2=CC=C(C(OC/C=C(C)\C)=C2)OC)=O)=CC(OC)=C1OC
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

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Anticancer agent 195 Related Classifications

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  • Do most proteins show cross-species activity?

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Keywords:

Anticancer agent 195Anticancer agent195Anticancer agent-195Apoptosisgastric cancerHER2NCI-N87trastuzumab resistanceTRNCI-N87 TRathymic nude miceInhibitorinhibitorinhibit

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Nombre del producto:
Anticancer agent 195
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HY-158005
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