2. Antidiabetic agent 8

Antidiabetic agent 8 is an orally active multi-target inhibitor, with IC50 values of 9.79, 6.36 and 19.08 μM against α-glucosidase, α-amylase and PTP1B, respectively. Antidiabetic agent 8 reduces postprandial blood glucose elevation. Antidiabetic agent 8 can be used in the research of type 2 diabetes.

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Antidiabetic agent 8

Antidiabetic agent 8 Chemical Structure

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Antidiabetic agent 8 Related Antibodies

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Description

Antidiabetic agent 8 is an orally active multi-target inhibitor, with IC50 values of 9.79, 6.36 and 19.08 μM against α-glucosidase, α-amylase and PTP1B, respectively. Antidiabetic agent 8 reduces postprandial blood glucose elevation. Antidiabetic agent 8 can be used in the research of type 2 diabetes[1].

In Vitro

Antidiabetic agent 8 (compound 5l) shows low cytotoxicity against HEK-293 cells after 24 h, with an IC50 of 138.08 μM, which is much higher than its enzyme inhibitory concentration[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antidiabetic agent 8 Related Antibodies
In Vivo

Antidiabetic agent 8 (compound 5l) (20 mg/kg; p.o.; single dose) reduces the postprandial blood glucose AUC0-t by 12.08% in normal mice subjected to oral sucrose loading[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: KM mice (male, 8-week-old)[1]
Dosage: 20 mg/kg
Administration: p.o.; single dose
Result: Reduced the area under the blood glucose curve (AUC) by 12.08% relative to the control group.
Molecular Weight

496.38

Formula

C23H18BrN3O3S
SMILES

OC(C=C1)=CC=C1C(O2)=NN=C2SCC(O)CN3C4=C(C=CC(Br)=C4)C5=C3C=CC=C5
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Antidiabetic agent 8 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antidiabetic agent 8Antidiabetic agent8Antidiabetic agent-8HEK-293 cellspostprandial blood glucoseα-amylaseSaccharomyces cerevisiaetype 2 diabetestyrosine residuesα-glucosidasePTP1Bhog pancreastryptophan residuesInhibitorinhibitorinhibit

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