2. PROTAC Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. Molecular Glues Androgen Receptor E1/E2/E3 Enzyme
  4. AR Degrader-1

AR Degrader-1 (Compound ML 2-9) is a molecular glue androgen receptor (AR) monovalent degrader. AR Degrader-1 degrades AR through DCAF16 (E3 ligase) without obvious cytotoxicity in LNCaP prostate cancer cells.

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AR Degrader-1

AR Degrader-1 Chemische Struktur

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AR Degrader-1 Related Antibodies

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Beschreibung

AR Degrader-1 (Compound ML 2-9) is a molecular glue androgen receptor (AR) monovalent degrader. AR Degrader-1 degrades AR through DCAF16 (E3 ligase) without obvious cytotoxicity in LNCaP prostate cancer cells[1].

Molekulargewicht

531.03

Formel

C24H27ClN6O4S
SMILES

O=C(C1=NN=C(N2CCN(S(=O)(C=C)=O)CC2)C=C1)N[C@H]3CC[C@H](OC4=CC=C(C#N)C(Cl)=C4)CC3
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
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AR Degrader-1 Related Classifications

  • Molaritätsrechner

  • Verdünnungsrechner

Die Formel zur Berechnung von Molaritäten

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)

Diese Gleichung wird häufig abgekürzt als: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AR Degrader-1AR Degrader1AR Degrader 1Molecular GluesAndrogen ReceptorE1/E2/E3 EnzymeE1 activating enzymeE2 conjugating enzymeE3 ligating enzymeUbiquitin activating enzymeUbiquitin conjugating enzymeUbiquitin ligaseLNCaPprostate cancerInhibitorinhibitorinhibit

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