(Arg)9,TAMRA-labeled acetate
Based on 1 Customer Validation
(Arg)9,TAMRA-labeled acetate is a TAMRA-labeled, membrane-permeable cationic cell-penetrating polyarginine peptide. (Arg)9,TAMRA-labeled acetate acts as a cell-penetrating peptide for drug delivery.
For research use only. We do not sell to patients.
- Purity: 98.68%
- Formula: C79H130N38O14.xC2H4O2
- Molecular Weight:1836.12 (free base)
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Biological Activity
(Arg)9,TAMRA-labeled acetate (1-5 μM; 3 h, overnight at 37 °C) shows low, dose-dependent permeation into NIH 3T3 mouse embryonic fibroblast cells, with no statistically significant difference in permeation between 37 °C (active endocytosis plus passive diffusion) and 4 °C (passive diffusion only) at 2 μM[1].
(Arg)9,TAMRA-labeled acetate (5 μM; 3 h at 37 °C) shows low permeation into NIH 3T3 mouse embryonic fibroblast cells, as indicated by sparse punctate intracellular fluorescence[1].
(Arg)9,TAMRA-labeled acetate (10 μM; 24 or 48 h at 37 °C) shows no significant cytotoxicity toward NIH 3T3 mouse embryonic fibroblast cells[1].
(Arg)9,TAMRA-labeled acetate (2 μM; 3 h at 37 °C or 4 °C) shows low permeation into H9 human embryonic stem cells, with no statistically significant difference in permeation between 37 °C and 4 °C, and a bimodal fluorescence distribution at 37 °C[1].
(Arg)9,TAMRA-labeled acetate (5 μM; 3 h at 37 °C) shows low permeation into H9 human embryonic stem cells, as indicated by sparse punctate intracellular fluorescence in cell colonies[1].
(Arg)9,TAMRA-labeled acetate (10 μM; 24 or 48 h at 37 °C) shows no significant cytotoxicity toward H9 human embryonic stem cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:NIH 3T3 mouse embryonic fibroblast cells
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Concentration:10 μM
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Incubation Time:24 h; 48 h at 37 °C
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Result:Caused no significant difference in NIH 3T3 cell viability relative to vehicle controls or other peptides.
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Cell Line:H9 human embryonic stem cells
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Concentration:10 μM
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Incubation Time:24 h; 48 h at 37 °C
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Result:Caused no significant difference in H9 human embryonic stem cell viability relative to vehicle controls or other peptides.
(Arg)9,TAMRA-labeled acetate (20 μM; in solution; overnight; room temperature) achieves notable internal permeation in dechorionated-and-dewaxed Drosophila melanogaster embryos, with viability loss unrelated to reagent exposure and all treated hosts remaining in the embryo stage[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Drosophila melanogaster[1]
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Dosage:20 μM
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Administration:in solution; overnight; room temperature
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Result:Showed no adsorption onto the outer membrane and no permeation into the interior of dechorionated hosts.
Prevented transition to the larval stage in treated hosts.
Caused no viability loss in treated hosts.\nAchieved notable permeation into the interior of dechorionated-and-dewaxed hosts.
Caused viability loss among treated hosts, unrelated to reagent exposure.
Resulted in all treated hosts remaining in the embryo stage.
Chemical Information
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Appearance Solid
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Molecular Weight 1836.12 (free base)
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Formula C79H130N38O14.xC2H4O2
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Color Brown to reddish brown
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Sequence
TAMRA-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg
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Sequence Shortening
TAMRA-RRRRRRRRR
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H2O : 50 mg/mL (Need ultrasonic)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
- (Arg)9,TAMRA-labeled
- Fluorescent Dye
- Drosophila melanogaster larvae
- cell permeation assays
- mouse embryonic fibroblast cells
- Drosophila melanogaster embryos
- endocytosis
- human embryonic stem cells
- embryo permeation assays
- cell-permeating poly-arginine peptide
- NIH 3T3 mouse embryonic fibroblast cells
- H9 human embryonic stem cells
- Inhibitor
- inhibitor
- inhibit