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  4. (Arg)9,TAMRA-labeled acetate

(Arg)9,TAMRA-labeled acetate is a TAMRA-labeled, membrane-permeable cationic cell-penetrating polyarginine peptide. (Arg)9,TAMRA-labeled acetate acts as a cell-penetrating peptide for drug delivery.

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(Arg)9,TAMRA-labeled acetate

(Arg)9,TAMRA-labeled acetate Chemical Structure

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(Arg)9,TAMRA-labeled acetate Related Antibodies

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Description

(Arg)9,TAMRA-labeled acetate is a TAMRA-labeled, membrane-permeable cationic cell-penetrating polyarginine peptide. (Arg)9,TAMRA-labeled acetate acts as a cell-penetrating peptide for drug delivery[1].

In Vitro

(Arg)9,TAMRA-labeled acetate (1-5 μM; 3 h, overnight at 37 °C) shows low, dose-dependent permeation into NIH 3T3 mouse embryonic fibroblast cells, with no statistically significant difference in permeation between 37 °C (active endocytosis plus passive diffusion) and 4 °C (passive diffusion only) at 2 μM[1].
(Arg)9,TAMRA-labeled acetate (5 μM; 3 h at 37 °C) shows low permeation into NIH 3T3 mouse embryonic fibroblast cells, as indicated by sparse punctate intracellular fluorescence[1].
(Arg)9,TAMRA-labeled acetate (10 μM; 24 or 48 h at 37 °C) shows no significant cytotoxicity toward NIH 3T3 mouse embryonic fibroblast cells[1].
(Arg)9,TAMRA-labeled acetate (2 μM; 3 h at 37 °C or 4 °C) shows low permeation into H9 human embryonic stem cells, with no statistically significant difference in permeation between 37 °C and 4 °C, and a bimodal fluorescence distribution at 37 °C[1].
(Arg)9,TAMRA-labeled acetate (5 μM; 3 h at 37 °C) shows low permeation into H9 human embryonic stem cells, as indicated by sparse punctate intracellular fluorescence in cell colonies[1].
(Arg)9,TAMRA-labeled acetate (10 μM; 24 or 48 h at 37 °C) shows no significant cytotoxicity toward H9 human embryonic stem cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(Arg)9,TAMRA-labeled acetate Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: NIH 3T3 mouse embryonic fibroblast cells
Concentration: 10 μM
Incubation Time: 24 h; 48 h at 37 °C
Result: Caused no significant difference in NIH 3T3 cell viability relative to vehicle controls or other peptides.

Cell Cytotoxicity Assay[1]

Cell Line: H9 human embryonic stem cells
Concentration: 10 μM
Incubation Time: 24 h; 48 h at 37 °C
Result: Caused no significant difference in H9 human embryonic stem cell viability relative to vehicle controls or other peptides.
In Vivo

(Arg)9,TAMRA-labeled acetate (20 μM; in solution; overnight; room temperature) shows no membrane adsorption or internal permeation in dechorionated Drosophila melanogaster embryos/larvae, with no viability loss or larval transition observed in treated hosts[1].
(Arg)9,TAMRA-labeled acetate (20 μM; in solution; overnight; room temperature) achieves notable internal permeation in dechorionated-and-dewaxed Drosophila melanogaster embryos, with viability loss unrelated to reagent exposure and all treated hosts remaining in the embryo stage[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Drosophila melanogaster[1]
Dosage: 20 μM
Administration: in solution; overnight; room temperature
Result: Showed no adsorption onto the outer membrane and no permeation into the interior of dechorionated hosts.
Prevented transition to the larval stage in treated hosts.
Caused no viability loss in treated hosts.\nAchieved notable permeation into the interior of dechorionated-and-dewaxed hosts.
Caused viability loss among treated hosts, unrelated to reagent exposure.
Resulted in all treated hosts remaining in the embryo stage.
Molecular Weight

1836.12 (free base)

Formula

C79H130N38O14.xC2H4O2
Appearance

Solid

Color

Brown to reddish brown

Sequence

TAMRA-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg
Sequence Shortening

TAMRA-RRRRRRRRR
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (Need ultrasonic)

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This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
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(Arg)9,TAMRA-labeled acetate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(Arg)9,TAMRA-labeledFluorescent DyeDrosophila melanogaster larvaecell permeation assaysmouse embryonic fibroblast cellsDrosophila melanogaster embryosendocytosishuman embryonic stem cellsembryo permeation assayscell-permeating poly-arginine peptideNIH 3T3 mouse embryonic fibroblast cellsH9 human embryonic stem cellsInhibitorinhibitorinhibit

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