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Art. -Nr.: HY-118124

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2-Iodoestradiol

2-Iodoestradiol is a potent human sex hormone binding globulin (SHBG) ligand with a remarkably high affinity for SHBG. 2-Iodoestradiol exhibits competition for the same binding site as dihydrotestosterone in binding to human SHBG. The binding affinity constant of 2-Iodoestradiol at physiological pH and 37 degrees Celsius is 2.4 x 10(9) M-1, exceeding that for SHBG. 2-Iodoestradiol has been shown to bind to serum albumin, but with lower affinity. The radioisotope 125I-derivative of 2-Iodoestradiol has been used to study the binding properties of human SHBG, demonstrating its potential application in biological research.

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CAS. Nr.: 24381-12-2
Formel: C₁₈H₂₃IO₂
Molecular Weight:398.28

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

2-Iodoestradiol Chemical Structure

CAS. Nr.: 24381-12-2

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Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
DU-145	GI₅₀	6.9 μM Compound: 14	Cytotoxicity against prostate DU-145 cancer cell lines. Cytotoxicity against prostate DU-145 cancer cell lines.	[PMID: 7783135]
HCT-116	GI₅₀	5 μM Compound: 14	Cytotoxicity against colon HCT116 cancer cell lines. Cytotoxicity against colon HCT116 cancer cell lines.	[PMID: 7783135]
HOP-62	GI₅₀	4.2 μM Compound: 14	Cytotoxicity against lung HOP-62 cancer cell lines. Cytotoxicity against lung HOP-62 cancer cell lines.	[PMID: 7783135]
MDA-MB-435	GI₅₀	2.1 μM Compound: 14	Cytotoxicity against breast MDA-MB-435 cancer cell lines. Cytotoxicity against breast MDA-MB-435 cancer cell lines.	[PMID: 7783135]
OVCAR-3	GI₅₀	3.5 μM Compound: 14	Cytotoxicity against ovarian OVCAR-3 cancer cell lines. Cytotoxicity against ovarian OVCAR-3 cancer cell lines.	[PMID: 7783135]
Panel (Carcinoma cell lines)	GI₅₀	5.5 μM Compound: 14	Mean graph midpoint for all human cancer cell line cytotoxicity. Mean graph midpoint for all human cancer cell line cytotoxicity.	[PMID: 7783135]
SF-539	GI₅₀	3 μM Compound: 14	Cytotoxicity against CNS SF-539 cancer cell lines. Cytotoxicity against CNS SF-539 cancer cell lines.	[PMID: 7783135]
SN12C	GI₅₀	6.6 μM Compound: 14	Cytotoxicity against renal SN12C cancer cell lines. Cytotoxicity against renal SN12C cancer cell lines.	[PMID: 7783135]
UACC-62	GI₅₀	3.6 μM Compound: 14	Cytotoxicity against melanoma UACC-62 cancer cell lines. Cytotoxicity against melanoma UACC-62 cancer cell lines.	[PMID: 7783135]

Chemical Information

CAS. Nr. 24381-12-2
Molecular Weight 398.28
Formel C₁₈H₂₃IO₂
SMILES

C[C@@]12[C@](CC[C@@H]2O)([H])[C@@]3([H])[C@@](CC1)([H])C4=CC(I)=C(O)C=C4CC3
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. 2-Iodoestradiol binds with high affinity to human sex hormone binding globulin (SHBG)

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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2-Iodoestradiol

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

2-Iodoestradiol Related Classifications

HY-118124 Related Classifications