NTMT1 - N-terminal Xaa-Pro-Lys N-methyltransferase 1 Gene

Also Known as NRMT; NRMT1; NTM1A; AD-003; HOMT1A; C9orf32; METTL11A

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 28989

About NTMT1

Cytogenetic location: 9q34.11 Genomic coordinates (GRCh38): 9:129,608,872-129,636,135 (from NCBI)

This gene has 11 transcripts (splice variants), 198 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 16.4), adrenal (RPKM 9.8) and 25 other tissues.

Summary

The METTL11A gene encodes an N-terminal methyltransferase for the RAN (MIM 601179) guanine nucleotide exchange factor regulator of chromosome condensation 1 (RCC1; MIM 179710). METTL11A enzyme alpha-N-methylates Other protein targets such as SET (MIM 600960) and RB (MIM 180200).[supplied by OMIM, Nov 2010]

NTMT1 Products (9)

mRNA Protein Name
NM_001286796.2 NP_001273725.1 N-terminal Xaa-Pro-Lys N-methyltransferase 1 isoform a
NM_001286797.2 NP_001273726.1 N-terminal Xaa-Pro-Lys N-methyltransferase 1 isoform a
NM_001286798.2 NP_001273727.1 N-terminal Xaa-Pro-Lys N-methyltransferase 1 isoform a
NM_001286799.2 NP_001273728.1 N-terminal Xaa-Pro-Lys N-methyltransferase 1 isoform a
NM_001286800.2 NP_001273729.1 N-terminal Xaa-Pro-Lys N-methyltransferase 1 isoform b
NM_001286801.2 NP_001273730.1 N-terminal Xaa-Pro-Lys N-methyltransferase 1 isoform b
NM_001286802.2 NP_001273731.1 N-terminal Xaa-Pro-Lys N-methyltransferase 1 isoform c
NM_001286803.2 NP_001273732.1 N-terminal Xaa-Pro-Lys N-methyltransferase 1 isoform c
NM_014064.4 NP_054783.2 N-terminal Xaa-Pro-Lys N-methyltransferase 1 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables N-terminal protein N-methyltransferase activity IDA
IDA: Inferred from direct assay
26543159 GOA
enables histone methyltransferase activity IDA
IDA: Inferred from direct assay
26543159 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
20668449 GOA
enables protein methyltransferase activity IDA
IDA: Inferred from direct assay
20481588 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in N-terminal peptidyl-glycine methylation IDA
IDA: Inferred from direct assay
26543159 GOA
involved in N-terminal peptidyl-proline dimethylation IDA
IDA: Inferred from direct assay
20481588 GOA
involved in N-terminal peptidyl-serine dimethylation IDA
IDA: Inferred from direct assay
20668449 GOA
involved in N-terminal peptidyl-serine trimethylation IDA
IDA: Inferred from direct assay
20668449 GOA
involved in chromosome segregation IMP
IMP: Inferred from mutant phenotype
20668449 GOA
involved in spindle organization IMP
IMP: Inferred from mutant phenotype
20668449 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in nucleus IDA
IDA: Inferred from direct assay
20668449 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NTMT1 Protein Structure

Methyltransf_PK

Methyltransf_PK: AdoMet dependent proline di-methyltransferase (8 - 223)

  • 0
  • 100
  • 200
  • 223 a.a.
Protein Preferred Names Protein Names

N-terminal Xaa-Pro-Lys N-methyltransferase 1

  • N-terminal RCC1 methyltransferase

NTMT1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
NTMT1 Q9BV86 GLYR1 Homo sapiens Q49A26-4
Y2H Array
32296183
Intra
NTMT1 Q9BV86 GLYR1 Homo sapiens Q49A26-4
Y2H Prey Pooling
32296183
Intra
NTMT1 Q9BV86 RCC1 Homo sapiens P18754
ITC
20668449
Intra
NTMT1 Q9BV86 RCC1 Homo sapiens P18754
Methyltransferase Ass
20668449
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant NTMT1 Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P77447 METTL11A Protein, Human Q9BV86-1 (T2-R223) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P77448 METTL11A Protein, Human (GST) Q9BV86-1 (T2-R223) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-P10407 BM30 Inhibitor 99.45% Unkown
HY-182676 DC541 Inhibitor / Unkown
HY-P10028 DC432 / Unkown
HY-RS09620 NTMT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19025 Ntmt1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25514 Ntmt1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris NTMT1 VGNC VGNC:44006
Bos taurus NTMT1 VGNC VGNC:32303
Felis catus NTMT1 VGNC VGNC:102959
Macaca mulatta NTMT1 VGNC VGNC:75451
Mus musculus NTMT1 MGD MGI:1913867
Rattus norvegicus NTMT1 RGD RGD:1306582
Others NTMT1 NCBI