HDAC6-IN-19
HDAC6-IN-19 (Compound 14g) is a HDAC6 inhibitor (IC50: 2.68 nM). HDAC6-IN-19 also inhibits HDAC1, HDAC2 and HDAC3 with IC50s of 61.6 nM, 98.7 nM and 103 nM. HDAC6-IN-19 potently inhibits multiple cancer cell proliferation, including leukemia, colon cancer, melanoma, and breast cancer cell lines.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Formel: C26H23ClN4O3
- Molecular Weight:474.94
-
Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biologische Aktivität
2.68 nM, 61.6 nM, 98.7 nM and 103 nM (HDAC6, HDAC1, HDAC2 and HDAC3)[1]
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| 786-0 | GI50 |
3.71 μM
Compound: 14g
|
Antiproliferative activity against human 786-0 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
Antiproliferative activity against human 786-0 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
|
[PMID: 37660484] |
| A498 | GI50 |
2.06 μM
Compound: 14g
|
Antiproliferative activity against human A498 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
Antiproliferative activity against human A498 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
|
[PMID: 37660484] |
| A549 | GI50 |
3.97 μM
Compound: 14g
|
Antiproliferative activity against human A549 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
Antiproliferative activity against human A549 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
|
[PMID: 37660484] |
| ACHN | GI50 |
3.05 μM
Compound: 14g
|
Antiproliferative activity against human ACHN cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
Antiproliferative activity against human ACHN cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
|
[PMID: 37660484] |
| BT-549 | GI50 |
4.93 μM
Compound: 14g
|
Antiproliferative activity against human BT-549 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
Antiproliferative activity against human BT-549 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
|
[PMID: 37660484] |
| CAKI-1 | GI50 |
2.33 μM
Compound: 14g
|
Antiproliferative activity against human CAKI-1 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
Antiproliferative activity against human CAKI-1 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
|
[PMID: 37660484] |
| CCRF-CEM | GI50 |
0.617 μM
Compound: 14g
|
Antiproliferative activity against human CCRF-CEM cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
Antiproliferative activity against human CCRF-CEM cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
|
[PMID: 37660484] |
| COLO 205 | GI50 |
0.719 μM
Compound: 14g
|
Antiproliferative activity against human COLO 205 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
Antiproliferative activity against human COLO 205 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
|
[PMID: 37660484] |
| DU-145 | GI50 |
1.08 μM
Compound: 14g
|
Antiproliferative activity against human DU-145 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
Antiproliferative activity against human DU-145 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
|
[PMID: 37660484] |
| EKVX | GI50 |
2.65 μM
Compound: 14g
|
Antiproliferative activity against human EKVX cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
Antiproliferative activity against human EKVX cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
|
[PMID: 37660484] |
| HCC 2998 | GI50 |
0.605 μM
Compound: 14g
|
Antiproliferative activity against human HCC 2998 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
Antiproliferative activity against human HCC 2998 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
|
[PMID: 37660484] |
| HCT-116 | GI50 |
0.609 μM
Compound: 14g
|
Antiproliferative activity against human HCT-116 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
Antiproliferative activity against human HCT-116 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
|
[PMID: 37660484] |
| HCT-15 | GI50 |
4.26 μM
Compound: 14g
|
Antiproliferative activity against human HCT-15 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
Antiproliferative activity against human HCT-15 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
|
[PMID: 37660484] |
| HL-60(TB) | GI50 |
0.706 μM
Compound: 14g
|
Antiproliferative activity against human HL-60(TB) cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
Antiproliferative activity against human HL-60(TB) cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
|
[PMID: 37660484] |
| HOP-62 | GI50 |
1.27 μM
Compound: 14g
|
Antiproliferative activity against human HOP-62 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
Antiproliferative activity against human HOP-62 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
|
[PMID: 37660484] |
| HOP-92 | GI50 |
0.93 μM
Compound: 14g
|
Antiproliferative activity against human HOP-92 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
Antiproliferative activity against human HOP-92 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
|
[PMID: 37660484] |
| Hs-578T | GI50 |
1.01 μM
Compound: 14g
|
Antiproliferative activity against human Hs-578T cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
Antiproliferative activity against human Hs-578T cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
|
[PMID: 37660484] |
| HT-29 | GI50 |
0.838 μM
Compound: 14g
|
Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
|
[PMID: 37660484] |
| IGROV-1 | GI50 |
1.2 μM
Compound: 14g
|
Antiproliferative activity against human IGROV-1 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
Antiproliferative activity against human IGROV-1 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
|
[PMID: 37660484] |
| K562 | GI50 |
0.72 μM
Compound: 14g
|
Antiproliferative activity against human K562 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
Antiproliferative activity against human K562 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
|
[PMID: 37660484] |
| KM12 | GI50 |
2.36 μM
Compound: 14g
|
Antiproliferative activity against human KM12 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
Antiproliferative activity against human KM12 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
|
[PMID: 37660484] |
| LOX IMVI | GI50 |
1.09 μM
Compound: 14g
|
Antiproliferative activity against human LOX IMVI cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
Antiproliferative activity against human LOX IMVI cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
|
[PMID: 37660484] |
| M14 | GI50 |
2.2 μM
Compound: 14g
|
Antiproliferative activity against human M14 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
Antiproliferative activity against human M14 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
|
[PMID: 37660484] |
| Malme-3M | GI50 |
0.41 μM
Compound: 14g
|
Antiproliferative activity against human Malme-3M cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
Antiproliferative activity against human Malme-3M cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
|
[PMID: 37660484] |
| MCF7 | GI50 |
0.874 μM
Compound: 14g
|
Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
|
[PMID: 37660484] |
| MDA-MB-231 | GI50 |
0.887 μM
Compound: 14g
|
Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
|
[PMID: 37660484] |
| MDA-MB-435 | GI50 |
0.959 μM
Compound: 14g
|
Antiproliferative activity against human MDA-MB-435 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
Antiproliferative activity against human MDA-MB-435 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
|
[PMID: 37660484] |
| MDA-MB-468 | GI50 |
0.38 μM
Compound: 14g
|
Antiproliferative activity against human MDA-MB-468 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
Antiproliferative activity against human MDA-MB-468 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
|
[PMID: 37660484] |
| MOLT-4 | GI50 |
0.563 μM
Compound: 14g
|
Antiproliferative activity against human MOLT-4 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
Antiproliferative activity against human MOLT-4 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
|
[PMID: 37660484] |
| NCI/ADR-RES | GI50 |
3.35 μM
Compound: 14g
|
Antiproliferative activity against human NCI-ADR-RES cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
Antiproliferative activity against human NCI-ADR-RES cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
|
[PMID: 37660484] |
| NCI-H226 | GI50 |
2.27 μM
Compound: 14g
|
Antiproliferative activity against human NCI-H226 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
Antiproliferative activity against human NCI-H226 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
|
[PMID: 37660484] |
| NCI-H23 | GI50 |
1.33 μM
Compound: 14g
|
Antiproliferative activity against human NCI-H23 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
Antiproliferative activity against human NCI-H23 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
|
[PMID: 37660484] |
| NCI-H322M | GI50 |
1.62 μM
Compound: 14g
|
Antiproliferative activity against human NCI-H322M cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
Antiproliferative activity against human NCI-H322M cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
|
[PMID: 37660484] |
| NCI-H460 | GI50 |
1.02 μM
Compound: 14g
|
Antiproliferative activity against human NCI-H460 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
Antiproliferative activity against human NCI-H460 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
|
[PMID: 37660484] |
| NCI-H522 | GI50 |
0.584 μM
Compound: 14g
|
Antiproliferative activity against human NCI-H522 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
Antiproliferative activity against human NCI-H522 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
|
[PMID: 37660484] |
| OVCAR-3 | GI50 |
1.23 μM
Compound: 14g
|
Antiproliferative activity against human OVCAR-3 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
Antiproliferative activity against human OVCAR-3 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
|
[PMID: 37660484] |
| OVCAR-4 | GI50 |
3.73 μM
Compound: 14g
|
Antiproliferative activity against human OVCAR-4 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
Antiproliferative activity against human OVCAR-4 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
|
[PMID: 37660484] |
| OVCAR-5 | GI50 |
0.456 μM
Compound: 14g
|
Antiproliferative activity against human OVCAR-5 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
Antiproliferative activity against human OVCAR-5 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
|
[PMID: 37660484] |
| OVCAR-8 | GI50 |
0.942 μM
Compound: 14g
|
Antiproliferative activity against human OVCAR-8 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
Antiproliferative activity against human OVCAR-8 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
|
[PMID: 37660484] |
| PC-3 | GI50 |
1.76 μM
Compound: 14g
|
Antiproliferative activity against human PC-3 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
Antiproliferative activity against human PC-3 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
|
[PMID: 37660484] |
| RPMI-8226 | GI50 |
0.564 μM
Compound: 14g
|
Antiproliferative activity against human RPMI-8226 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
Antiproliferative activity against human RPMI-8226 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
|
[PMID: 37660484] |
| RPMI-8226 | IC50 |
0.62 μM
Compound: 14g
|
Antiproliferative activity against human RPMI-8226 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
Antiproliferative activity against human RPMI-8226 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
|
[PMID: 37660484] |
| RXF 393 | GI50 |
0.455 μM
Compound: 14g
|
Antiproliferative activity against human RXF 393 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
Antiproliferative activity against human RXF 393 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
|
[PMID: 37660484] |
| SF-268 | GI50 |
2.92 μM
Compound: 14g
|
Antiproliferative activity against human SF-268 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
Antiproliferative activity against human SF-268 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
|
[PMID: 37660484] |
| SF-295 | GI50 |
1.81 μM
Compound: 14g
|
Antiproliferative activity against human SF-295 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
Antiproliferative activity against human SF-295 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
|
[PMID: 37660484] |
| SF-539 | GI50 |
1.14 μM
Compound: 14g
|
Antiproliferative activity against human SF-539 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
Antiproliferative activity against human SF-539 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
|
[PMID: 37660484] |
| SK-MEL-2 | GI50 |
2.77 μM
Compound: 14g
|
Antiproliferative activity against human SK-MEL-2 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
Antiproliferative activity against human SK-MEL-2 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
|
[PMID: 37660484] |
| SK-MEL-28 | GI50 |
0.878 μM
Compound: 14g
|
Antiproliferative activity against human SK-MEL-28 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
Antiproliferative activity against human SK-MEL-28 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
|
[PMID: 37660484] |
| SK-MEL-5 | GI50 |
0.721 μM
Compound: 14g
|
Antiproliferative activity against human SK-MEL-5 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
Antiproliferative activity against human SK-MEL-5 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
|
[PMID: 37660484] |
| SK-OV-3 | GI50 |
2.01 μM
Compound: 14g
|
Antiproliferative activity against human SK-OV-3 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
Antiproliferative activity against human SK-OV-3 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
|
[PMID: 37660484] |
| SN12C | GI50 |
2.41 μM
Compound: 14g
|
Antiproliferative activity against human SN12C cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
Antiproliferative activity against human SN12C cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
|
[PMID: 37660484] |
| SNB-19 | GI50 |
2.26 μM
Compound: 14g
|
Antiproliferative activity against human SNB-19 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
Antiproliferative activity against human SNB-19 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
|
[PMID: 37660484] |
| SNB-75 | GI50 |
2.26 μM
Compound: 14g
|
Antiproliferative activity against human SNB-75 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
Antiproliferative activity against human SNB-75 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
|
[PMID: 37660484] |
| SR | GI50 |
1.15 μM
Compound: 14g
|
Antiproliferative activity against human SR cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
Antiproliferative activity against human SR cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
|
[PMID: 37660484] |
| SW-620 | GI50 |
0.687 μM
Compound: 14g
|
Antiproliferative activity against human SW620 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
Antiproliferative activity against human SW620 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
|
[PMID: 37660484] |
| T47D | GI50 |
0.6 μM
Compound: 14g
|
Antiproliferative activity against human T47D cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
Antiproliferative activity against human T47D cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
|
[PMID: 37660484] |
| TK-10 | GI50 |
1.51 μM
Compound: 14g
|
Antiproliferative activity against human TK-10 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
Antiproliferative activity against human TK-10 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
|
[PMID: 37660484] |
| U-251 | GI50 |
1.21 μM
Compound: 14g
|
Antiproliferative activity against human U-251 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
Antiproliferative activity against human U-251 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
|
[PMID: 37660484] |
| UACC-257 | GI50 |
1.23 μM
Compound: 14g
|
Antiproliferative activity against human UACC-257 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
Antiproliferative activity against human UACC-257 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
|
[PMID: 37660484] |
| UACC-62 | GI50 |
0.538 μM
Compound: 14g
|
Antiproliferative activity against human UACC-62 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
Antiproliferative activity against human UACC-62 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
|
[PMID: 37660484] |
| UO-31 | GI50 |
2.64 μM
Compound: 14g
|
Antiproliferative activity against human UO-31 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
Antiproliferative activity against human UO-31 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
|
[PMID: 37660484] |
Chemical Information
-
Molecular Weight 474.94
-
Formel C26H23ClN4O3
-
SMILES
O=C([C@H]1CC2=C([C@H](C3=CC=C(Cl)C=C3)N1)NC4=C2C=CC=C4)NCC5=CC=C(C(NO)=O)C=C5
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)