country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Art. -Nr.: HY-159159

Copy Link Print Information

MS-II-124

Kundenbewertung

Based on 1 Customer Validation

MS-II-124 is an effective and selective NLRP3 inhibitor (IC₅₀=0.12 μM) with anti-inflammatory and immunomodulatory activities, which can be used in the research of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS).

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit: 99.66%
CAS. Nr.: 3037332-85-4
Formel: C₂₈H₂₈ClFN₂O₄S
Molecular Weight:543.05

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

MS-II-124 Chemical Structure

CAS. Nr.: 3037332-85-4

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vivo
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

IC50=0.12 μM (NLRP3)^[1].

Alle NOD-like Receptor (NLR) Isoform-spezifische Produkte anzeigen :

In Vivo

MS-II-124 (10 mg/kg; i.p.; single dose) reduces lung inflammation and immune cell infiltration in the LPS (HY-D1056) ( i.n. instillation, 40 μg in 40 μL PBS) -induced ALI/ARDS wild-type mouse model, exhibiting anti-inflammatory and immunomodulatory activities^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

ALI/ARDS WT C57BL/6 mice model^[1].
Dosage:

10 mg/kg
Administration:

Intraperitoneal injection (i.p.), Single dose. 1 h before i.n. instillation of LPS (40 μg in 40 μL PBS).
Result:

Significantly inhibited lipopolysaccharide (LPS)-induced IL-1β production in pulmonary bronchoalveolar lavage fluid (BALF), whereas NLRP3 deletion did not significantly inhibit its production.

Chemical Information

CAS. Nr. 3037332-85-4
Appearance Solid
Molecular Weight 543.05
Formel C₂₈H₂₈ClFN₂O₄S
Color White to off-white
SMILES

ClC1=CC=C(OCCC)C(CN(CCC2=CC=C(S(=O)(NCC#C)=O)C=C2)C(C3=CC=C(F)C=C3)=O)=C1
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 35 mg/mL (64.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.8415 mL

9.2073 mL

18.4145 mL

5 mM

0.3683 mL

1.8415 mL

3.6829 mL

10 mM

0.1841 mL

0.9207 mL

1.8415 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Xu Y, et al. Characterization of a small molecule inhibitor of the NLRP3 inflammasome and its potential use for acute lung injury[J]. Bioorganic Chemistry, 2024: 107562. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.8415 mL	9.2073 mL	18.4145 mL	46.0363 mL
	5 mM	0.3683 mL	1.8415 mL	3.6829 mL	9.2073 mL
	10 mM	0.1841 mL	0.9207 mL	1.8415 mL	4.6036 mL
	15 mM	0.1228 mL	0.6138 mL	1.2276 mL	3.0691 mL
	20 mM	0.0921 mL	0.4604 mL	0.9207 mL	2.3018 mL
	25 mM	0.0737 mL	0.3683 mL	0.7366 mL	1.8415 mL
	30 mM	0.0614 mL	0.3069 mL	0.6138 mL	1.5345 mL
	40 mM	0.0460 mL	0.2302 mL	0.4604 mL	1.1509 mL
	50 mM	0.0368 mL	0.1841 mL	0.3683 mL	0.9207 mL
	60 mM	0.0307 mL	0.1535 mL	0.3069 mL	0.7673 mL

Keywords

MOQ

Minimum order quantity

100 mg

Angebot einholen Auf Lager

Other size

Angebot einholen

Amount: USD 0.00

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vivo
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise

Produktname:
Art. -Nr.:
Menge:
MCE Japan Authorized Agent:

Produktname:
CAS. Nr.:
Species:
Reinheit:
Menge:

MS-II-124

Bioactive Compound Library Max

Bioactive Compound Library

Immunology/Inflammation Compound Library

NF-κB Signaling Compound Library

Antioxidant Compound Library

Oxygen Sensing Compound Library

Pyroptosis Compound Library

Antidepressant Compound Library

Membrane Receptor-targeted Compound Library

Autoimmune Disease Compound Library

Highly Selective Inhibitors Library

Inflammasomes related Compound Library

Radioprotector Library

MCE Bioactive Compound Library

High-Throughput Bioactive Compound Library

Pattern Recognition Receptors Library

Alkyne Compound Library

Alle NOD-like Receptor (NLR) Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

MS-II-124

Bioactive Compound Library Max

Bioactive Compound Library

Immunology/Inflammation Compound Library

NF-κB Signaling Compound Library

Antioxidant Compound Library

Oxygen Sensing Compound Library

Pyroptosis Compound Library

Antidepressant Compound Library

Membrane Receptor-targeted Compound Library

Autoimmune Disease Compound Library

Highly Selective Inhibitors Library

Inflammasomes related Compound Library

Radioprotector Library

MCE Bioactive Compound Library

High-Throughput Bioactive Compound Library

Pattern Recognition Receptors Library

Alkyne Compound Library

Alle NOD-like Receptor (NLR) Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

MS-II-124 Related Classifications

HY-159159 Related Classifications