CD33 - CD33 molecule Gene

Also Known as p67; SIGLEC3; SIGLEC-3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 945

About CD33

Cytogenetic location: 19q13.41 Genomic coordinates (GRCh38): 19:51,211,076-51,240,016 (from NCBI)

This gene has 7 transcripts (splice variants), 73 orthologues and 16 paralogues. Broad expression in spleen (RPKM 7.5), bone marrow (RPKM 6.6) and 19 other tissues.

Summary

Enables protein Phosphatase binding activity and sialic acid binding activity. Involved in several processes, including negative regulation of cytokine production; negative regulation of monocyte activation; and positive regulation of protein tyrosine Phosphatase activity. Located in several cellular components, including Golgi apparatus; external side of plasma membrane; and peroxisome. [provided by Alliance of Genome Resources, Apr 2022]

CD33 Products (3)

mRNA	Protein	Name
NM_001082618.2	NP_001076087.1	myeloid cell surface antigen CD33 isoform 2
NM_001177608.2	NP_001171079.1	myeloid cell surface antigen CD33 isoform 3 precursor
NM_001772.4	NP_001763.3	myeloid cell surface antigen CD33 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10206955	GOA
enables protein phosphatase binding	IPI IPI: Inferred from physical interaction	10556798	GOA
enables protein tyrosine phosphatase activator activity	IMP IMP: Inferred from mutant phenotype	10556798	GOA
enables sialic acid binding	IMP IMP: Inferred from mutant phenotype	7718872	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in Fc-gamma receptor signaling pathway	IDA IDA: Inferred from direct assay	10556798	GOA
involved in cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	7718872	GOA
involved in immune response-inhibiting signal transduction	IDA IDA: Inferred from direct assay	10887109	GOA
involved in negative regulation of interleukin-1 beta production	IMP IMP: Inferred from mutant phenotype	15597323	GOA
involved in negative regulation of interleukin-8 production	IMP IMP: Inferred from mutant phenotype	15597323	GOA
involved in negative regulation of monocyte activation	IDA IDA: Inferred from direct assay	15597323	GOA
involved in negative regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	15597323	GOA
involved in positive regulation of protein secretion	IMP IMP: Inferred from mutant phenotype	27044754	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	21278227	GOA
located in cell surface	IDA IDA: Inferred from direct assay	28747436	GOA
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	20660734	GOA
located in peroxisome	IDA IDA: Inferred from direct assay	28747436	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	21278227	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CD33 Protein Structure

V-set

0
100
200
300
364 a.a.

Protein Preferred Names	Protein Names
myeloid cell surface antigen CD33	CD33 antigen (gp67)

CD33 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CD33	P20138	KRT40	Homo sapiens	Q6A162	Y2H Array	25416956
Intra	CD33	P20138	KRT40	Homo sapiens	Q6A162	Validated Y2H	25416956
Intra	CD33	P20138	TTMP	Homo sapiens	Q5BVD1	Validated Y2H	32296183
Intra	CD33	P20138	RPRM	Homo sapiens	Q9NS64	Validated Y2H	32296183
Intra	CD33	P20138	S100A9	Homo sapiens	P06702	Affinity Chrom	24216507
Intra	CD33	P20138	S100A9	Homo sapiens	P06702	IF	24216507
Intra	CD33	P20138	S100A9	Homo sapiens	P06702	ELISA	24216507
Intra	CD33	P20138	S100A9	Homo sapiens	P06702	Anti Bait CoIP	24216507
Intra	CD33	P20138	KRT35	Homo sapiens	Q92764	Validated Y2H	32296183
Intra	CD33	P20138	KRT35	Homo sapiens	Q92764	Y2H Prey Pooling	32296183
Intra	CD33	P20138	KRT35	Homo sapiens	Q92764	Y2H Array	32296183
Intra	CD33	P20138	TNMD	Homo sapiens	Q9H2S6-2	Validated Y2H	32296183
Intra	CD33	P20138	TMEM243	Homo sapiens	Q9BU79	Validated Y2H	32296183
Intra	CD33	P20138	TMEM243	Homo sapiens	Q9BU79	Y2H Array	32296183
Intra	CD33	P20138	UBIAD1	Homo sapiens	Q9Y5Z9	Validated Y2H	32296183
Intra	CD33	P20138	TMBIM1	Homo sapiens	Q969X1	Validated Y2H	32296183
Intra	CD33	P20138	PTPN11	Homo sapiens	Q06124	Anti Bait CoIP	17947393
Intra	CD33	P20138	PTPN11	Homo sapiens	Q06124	Pull Down	17947393
Intra	CD33	P20138	THSD7A	Homo sapiens	Q9UPZ6	Validated Y2H	32296183
Intra	CD33	P20138	CXCL9	Homo sapiens	Q07325	Validated Y2H	32296183
Intra	CD33	P20138	EMD	Homo sapiens	P50402	Validated Y2H	32296183
Intra	CD33	P20138	GIMAP5	Homo sapiens	Q96F15	Validated Y2H	32296183
Intra	CD33	P20138	PTPN6	Homo sapiens	P29350	Pull Down	10206955
Intra	CD33	P20138	PTPN6	Homo sapiens	P29350	Pull Down	17947393
Intra	CD33	P20138	PTPN6	Homo sapiens	P29350	Anti Bait CoIP	17947393
Intra	CD33	P20138	PTPN6	Homo sapiens	P29350	Anti Bait CoIP	24216507
Intra	CD33	P20138	TMEM100	Homo sapiens	Q9NV29	Validated Y2H	32296183
Intra	CD33	P20138	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	25416956
Intra	CD33	P20138	KRT31	Homo sapiens	Q15323	Validated Y2H	32296183
Intra	CD33	P20138	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183
Intra	CD33	P20138	KRT31	Homo sapiens	Q15323	Y2H Array	32296183
Intra	CD33	P20138	KRT31	Homo sapiens	Q15323	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CD33 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72021	Siglec-3/CD33 Protein, Human (HEK293, Fc-Myc)	P20138-1 (D18-H259)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P72472	Siglec-3/CD33 Protein, Human (HEK293, Fc-His)	AAH28152.1 (D18-H259)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P73642	Siglec-3/CD33 Protein, Human (HEK293, hFc)	P20138-1/AAH28152.1 (D18-H259, R69G)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P73643	Siglec-3/CD33 Protein, Human (HEK293)	AAH28152 (D18-H259)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P73644	Siglec-3/CD33 Protein, Human (HEK293, His)	AAH28152 (D18-H259)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P77536	Siglec-3/CD33 Protein, Human (Biotinylated, HEK293, His)	AAH28152 (D18-H259)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P78407	Siglec-3/CD33 Protein, Human (HEK293, His-Avi)	P20138-1 (D18-H259)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78408	FITC-Labeled Siglec-3/CD33 Protein, Human (HEK293, His-Avi)	P20138-1 (D18-H259)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P701037	Siglec-3/CD33 Protein, Human (Biotinylated, HEK293, His-Avi)	P20138-1 (D18-H259)	≥ 95%, as determined by reducing SDS-PAGE.

CD33 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81563	CD33 Antibody (YA1308)	IHC-P, FC	Human
HY-P84163	CD33 Antibody (YA3860)	WB, IHC-P, FC, ELISA	Human
HY-P84163A	CD33 Antibody (YA3860)(PBS only)	WB, IHC-P, FC, ELISA	Human
HY-P84989	CD33 Antibody (YA4681)	ELISA, FC	Human
HY-P85023	CD33 Antibody (YA4715)	FC, ELISA	Human
HY-P85088	CD33 Antibody (YA4780)	WB, ELISA	Human

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Diseases	Alias
Childhood T-Cell Acute Lymphoblastic Leukemia	T-Cell Childhood Acute Lymphoblastic Leukemia Childhood Precursor T-Lymphoblastic Lymphoma/Leukemia T-Cell Childhood Acute Lymphocytic Leukemia Childhood T Lymphoblastic Leukemia/Lymphoma
Acute Promyelocytic Leukemia	Leukemia, Acute Promyelocytic Acute Myeloblastic Leukemia Type 3 Aml M3 APL Leukemia, Acute Promyelocytic, Somatic Aml With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Apml Acute Myeloblastic Leukemia 3 Acute Myeloid Leukemia With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Acute Myeloblastic Leukaemia Type 3 Acute Myeloid Leukaemia M3 Acute Myeloid Leukemia M3 Acute Promyelocytic Leukaemia M3 Anll Myeloid Leukemia, Acute, M3 Leukemia Promyelocytic Acute Leukemia, Promyelocytic, Acute Leukemia, Acute, Promyelocytic
Myeloid Leukemia	Myeloid Leukaemia Leukaemia Myelogenous Leukemia Myelogenous Myeloid Granulocytic Leukaemia Myeloid Granulocytic Leukemia Non-Lymphocytic Leukemia Leukemia, Myeloid Granulocytic Leukaemia Myelogenous Leukaemia Myeloid Leukaemia, Unspecified, Without Mention Of Remission
Myelodysplastic Syndrome	Myelodysplastic Syndromes Myelodysplasia MDS Myelodysplastic Syndrome Included Myelodysplastic Syndrome, Susceptibility To, Included Myelodysplastic Syndrome, Somatic Myelodysplastic Syndrome, Susceptibility To
Acute Biphenotypic Leukemia	Mixed Phenotype Acute Leukemia Acute Leukemia Of Ambiguous Lineage Acute Undifferentiated Leukemia Acute Leukemia Of Indeterminate Lineage Hybrid Acute Leukemia Mixed Lineage Acute Leukemia All With Myeloid Markers Aml With Lymphoid Markers Acute Leukemia Of Undetermined Lineage Bal Biphenotypic Acute Leukemia Undifferentiated Acute Leukemia Mpal Acute Myeloid Leukemia, Minimal Differentiation, Fab M0 Leukemia, Biphenotypic, Acute
Acute Basophilic Leukemia
Myeloid Sarcoma	Granulocytic Sarcoma Chloroma Extramedullary Myeloid Tumor Sarcoma, Granulocytic Sarcoma Granulocytic Sarcoma, Myeloid Myelosarcoma Myeloid Sarcoma Disease Myeloid Sarcoma Nos Myeloid Sarcoma Without Mention Of Remission
Central Nervous System Leukemia	Leukemia Of The Cns
Leukemia, Chronic Myeloid	Chronic Myeloid Leukemia Chronic Myelogenous Leukemia CML Chronic Granulocytic Leukemia Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib Chronic Myeloid Leukaemia Chronic Granulocytic Leukaemia Chronic Myelogenous Leukaemia Myeloid Leukemia, Chronic Leukemia, Chronic Myelogenous Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic Cml - Chronic Myelogenous Leukemia Cgl Chronic Myelocytic Leukemia Leukemia, Chronic Myeloid, Atypical ACML Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative Myeloid Leukemia Chronic Leukemia, Myeloid, Chronic Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative Cml- [Chronic Myeloid Leukaemia] Cgl - [Chronic Granulocytic Leukaemia] Chronic Myelocytic Leukaemia
Leukemia, Acute Lymphoblastic	Acute Lymphoblastic Leukemia ALL Acute Lymphocytic Leukemia Leukemia, Acute Lymphocytic, Susceptibility To, 1 Acute Lymphoblastic Leukaemia Precursor Lymphoblastic Lymphoma/Leukemia Precursor Lymphoid Neoplasm Leukemia, Acute Lymphoblastic, Susceptibility To B-Cell Acute Lymphoblastic Leukemia Leukemia, Acute Lymphocytic 1 Acute Lymphocytic Leukaemia Acute Lymphoblastic Leukemia/Lymphoma All1 Childhood Acute Lymphoblastic Leukemia Leukemia Acute Lymphoblastic 1 Leukemia Acute Lymphoblastic B-Hyperdiploid Leukemia Acute Lymphocytic Leukemia Acute Lymphocytic 1 Leukemia B-Cell Acute Lymphoblastic Leukemia T-Cell Acute Lymphoblastic Leukemia, Acute Lymphoblastic, 3 ALL3 Lymphoblastic Leukemia Acute Leukemia, Acute, Lymphoblastic Precursor Cell Lymphoblastic Leukemia Lymphoma Leukemia, Lymphocytic, Acute, L1 Leukemia, Acute Lymphoblastic, Susceptibility To, 3
Hepatic Veno-Occlusive Disease	Veno-Occlusive Disease Sinusoidal Obstruction Syndrome Hepatic Venoocclusive Disease Venoocclusive Disease Hepatic Vein Thrombosis Budd-Chiari Syndrome Hepatic Vein Occlusion Veno-Occlusive Disease Of The Liver
Myeloproliferative Syndrome, Transient	Transient Abnormal Myelopoiesis Transient Myeloproliferative Syndrome Transient Myeloproliferative Disease Mst Tam Leukemia, Transient, Of Down Syndrome Tmd Leukemia, Transient Transient Leukemia Transient Leukemia Of Down Syndrome
Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy 1	Nasu-Hakola Disease Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy Plosl Nhd Presenile Dementia With Bone Cysts Plo-Sl PLOSL1 Dementia, Prefrontal, With Bone Cysts Dementia, Progressive, With Lipomembranous Polycystic Osteodysplasia Brain-Bone-Fat Disease Progressive Dementia With Lipomembranous Polycystic Osteodysplasia Brain-Bone-Fat Disease
Malignant Giant Cell Tumor Of The Tendon Sheath	Giant Cell Tumour Of Tendon Sheath, Malignant Malignant Giant Cell Neoplasm Of The Tendon Sheath
Childhood Acute Myeloid Leukemia	Childhood Acute Myeloid Leukaemia Paediatric Acute Myeloid Leukaemia Pediatric Acute Myeloid Leukemia
B-Cell Adult Acute Lymphocytic Leukemia	Adult B Acute Lymphoblastic Leukemia Adult B Acute Lymphoblastic Leukaemia Adult B-Cell Acute Lymphoblastic Leukaemia Adult B-Cell Acute Lymphoblastic Leukemia Adult B-Cell Lymphocytic Leukaemia Adult B-Cell Lymphocytic Leukemia Adult B-Lymphoblastic Leukaemia Adult B-Lymphoblastic Leukemia B-Cell Adult Acute Lymphocytic Leukaemia B-Cell Adult Acute Lymphoblastic Leukemia
B-Lymphoblastic Leukemia/Lymphoma	B Lymphoblastic Leukemia/Lymphoma B-All Precursor B Lymphoblastic Lymphoma/Leukemia C-All Lymphoblastic Lymphoma, Nos Common Precursor B All Lymphoblastic B-Cell Lymphoma Pro-B All B-Precursor Lymphoma Lbl - [Lymphoblastic Lymphoma]
Hepatic Vascular Disease	Vascular Disorder Of Liver
Adult Acute Lymphocytic Leukemia	Adult Acute Lymphoid Leukemia Adult All
Chronic Leukemia	Adult Chronic Leukemia Cll Cml
Childhood Leukemia
Acute Myeloid Leukemia With Bcr-Abl1	Acute Myeleoid Leukemia With Bcr-Abl1
Leukemia, Acute Monocytic	Acute Monocytic Leukemia Acute Monoblastic Leukemia And Acute Monocytic Leukemia Acute Monocytic Leukaemia Acute Monocytic Leukaemia Without Mention Of Remission Acute Monocytic Leukemia Without Mention Of Remission Acute Monocytic Leukemia, Fab M5 Acute Monocytic Leukemia, Morphology Leukemia, Monocytic, Acute M5b Acute Differentiated Monocytic Leukemia
Bone Marrow Cancer	Malignant Neoplasm Of Bone Marrow Bone Marrow Neoplasm Bone Marrow Tumor Malignant Bone Marrow Tumor Myeloproliferative Disorders Bone Marrow Neoplasms Myeloproliferative Disease Chronic Myeloproliferative Disorder
Precursor T-Cell Acute Lymphoblastic Leukemia	T-All Precursor T-Cell Acute Lymphoblastic Leukemia/Lymphoma Precursor T-Cell Acute Lymphocytic Leukemia Precursor T-Cell Acute Lymphocytic Leukemia/Lymphoma Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Adult T-Cell Lymphoma/Leukemia
Pancytopenia
Chronic Myelomonocytic Leukemia	Leukemia, Myelomonocytic, Chronic Cmml Leukemia Myelomonocytic Chronic Cmml - [Chronic Myelomonocytic Leukaemia] Chronic Myelomonocytic Leukaemia Without Mention Of Remission Chronic Monocytic Leukaemia Chronic Monocytoid Leukaemia
Bronchiectasis 1
Cardiomyopathy, Dilated, 1c, With Or Without Left Ventricular Noncompaction	Left Ventricular Noncompaction 3 Dilated Cardiomyopathy 1c CMD1C Cardiomyopathy, Hypertrophic, 24 Dilated Cardiomyopathy With Left Ventricular Noncompaction Cardiomyopathy, Dilated, 1c, With Or Without Lvnc Cmdc1 Dilated Cardiomyopathy 1c With Or Without Left Ventricular Noncompaction Cardiomyopathy, Dilated 1c, With Or Without Left Ventricular Non-Compaction Cardiomyopathy Dilated With Left Ventricular Noncompaction Cardiomyopathy, Familial Hypertrophic 24 CMH24 Left Ventricular Non-Compaction 3 LVNC3 Cardiomyopathy, Dilated 1c Familial Hypertrophic Cardiomyopathy 24 Cardiomyopathy, Dilated, 1c
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Acute Megakaryocytic Leukemia	Acute Megakaryoblastic Leukemia Acute Megakaryoblastic Leukaemia Megakaryocytic Myelosis Thrombocytic Leukaemia Amkl Aml M7 Acute Myeloblastic Leukemia Type 7 Acute Myeloid Leukemia M7 Megakaryoblastic Leukemia Acute Leukemia, Megakaryoblastic, Acute Acute Myeloid Leukaemia, M7 Acute Megakaryocytic Leukaemia Acute Megakaryoblastic Leukaemia, Fab M7 Fab M7 Malignant Megakaryocytosis M7 - Acute Megakaryoblastic Leukaemia Megakaryoblastic Leukaemia Megakaryocytic Leukaemia Acute Megakaryoblastic Leukaemia, Nos Acute Megakaryoblastic Leukaemia Without Mention Of Remission
Blood Platelet Disease	Platelet Disorder Blood Platelet Disorders Thrombocytopathy Platelet Dysfunction Platelet Disorders Qualitative Platelet Deficiency
Juvenile Myelomonocytic Leukemia	Leukemia, Juvenile Myelomonocytic JMML Leukemia, Juvenile Myelomonocytic, Somatic Juvenile Chronic Myelomonocytic Leukemia Juvenile Chronic Myelogenous Leukemia Leukemia, Myelomonocytic, Juvenile Juvenile Myelomonocytic Leukaemia Without Mention Of Remission
Myeloma, Multiple	Multiple Myeloma Plasma Cell Myeloma Kahler Disease Myelomatosis Medullary Plasmacytoma Multiple Myeloma, Resistance To Myeloma Plasma Cell Dyscrasia Kahler'S Disease Multiple Myeloma, Susceptibility To Myeloma - Multiple Kahler-Bozzolo Disease Plasma Cell Myelomas MM Plasma Cell Neoplasm Primary Systemic Amyloidosis Primary Amyloidosis Immunoglobulin Deposition Disease Plasmacytic Myeloma Multiple Myelomata Multiple Myeloma Nos Multiple Myeloma Without Mention Of Remission Monostotic Plasma Cell Myeloma Mm - [Multiple Myeloma]
Bilirubin Metabolic Disorder	Hyperbilirubinemia Hereditary Hyperbilirubinemia Hyperbilirubinemia, Hereditary Hyperbilirubinaemia
Leukemia, Chronic Lymphocytic	Chronic Lymphocytic Leukemia B-Cell Chronic Lymphocytic Leukemia CLL B-Cell Chronic Lymphoid Leukemia Chronic Lymphatic Leukemia Chronic Lymphocytic Leukaemia Lymphoplasmacytic Leukemia Small Lymphocytic Lymphoma Leukemia, Chronic Lymphatic B-Cell Chronic Lymphocytic Leukaemia Chronic Lymphatic Leukaemia Lymphoplasmacytic Leukaemia B Cell Chronic Lymphocytic Leukemia Chronic B-Cell Lymphocytic Leukemia Leukemia, Lymphocytic, Chronic B-Cll Chronic Lymphoid Leukemia Leukemia Lymphocytic Chronic Lymphoma Small Lymphocytic Leukemia, Lymphocytic, Chronic, B-Cell

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-109539	Gemtuzumab ozogamicin	Inducer	98.00%	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-171792	BMS-986497	Inhibitor	/	Phase 1

Inhibitory Antibodies (6)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99971	Gemtuzumab		99.54%	Phase 4
HY-P99329	Vadastuximab		99.23%	Phase 3
HY-P9983	Lintuzumab	Inhibitor	98.09%	Phase 3
HY-P99910	Eluvixtamab	Ligand	97.28%	Phase 1
HY-P99958	Vixtimotamab	Inhibitor	97.29%	Phase 1
HY-P991364	Aldastotug	Inhibitor	99.9%	Phase 1

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-144399	CD33 splicing modulator 1	Inhibitor	99.05%	Unkown
HY-160649	MC-Gly-Gly-Phe-Gly-GABA-Exatecan	Inhibitor	99.72%	Unkown
HY-109539A	Gemtuzumab ozogamicin (solution)	Inducer	/	Unkown
HY-144399A	CD33 splicing modulator 1 hydrochloride	Modulator	/	Unkown
HY-RS02235	CD33 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17093	Cd33 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23537	Cd33 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990903	Avitotamig	Inhibitor	95.98%	Unkown
HY-P991365	DS-1501	Inhibitor	/	Unkown
HY-P990505	Anti-Siglec-15/CD33L3 Antibody	Inhibitor	98.6674%	Unkown
HY-P991517	BI-836858		95.81%	Unkown
HY-P9S0124	Anti-CD33 Antibody (OR000283)		99.00%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CD33	MGD	MGI:99440
Rattus norvegicus	CD33	RGD	RGD:1596020
Macaca mulatta	CD33	VGNC	VGNC:81368
Others	CD33	NCBI