2. Inhibitory Antibodies
  3. Vixtimotamab

Vixtimotamab  (Synonyms: AMV-564; TandAb T564)

Cat. No.: HY-P99958

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Vixtimotamab (AMV-564; TandAb T564) is a bispecific tetravalent tandem diabody (TandAb) that targets human CD33 and human CD3 antigens. Vixtimotamab can be used for the research of acute myeloid leukemia (AML).

For research use only. We do not sell to patients.

Vixtimotamab Chemical Structure

Vixtimotamab Chemical Structure

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Vixtimotamab Related Antibodies

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Description

Vixtimotamab (AMV-564; TandAb T564) is a bispecific tetravalent tandem diabody (TandAb) that targets human CD33 and human CD3 antigens. Vixtimotamab can be used for the research of acute myeloid leukemia (AML)[1].

IC50 & Target

KD: 0.3 nM (CD33, HL-60 cells), 5.1 nM (CD3, Human T cells)[1]
In Vitro

Vixtimotamab (TandAb T564; 24 h) induces CD25 and CD69 with EC50s of 1 pM and 2 pM, respectively[1].
Vixtimotamab (TandAb T564; 4 days) induces T-cell proliferation in PBMCs with an EC50 of 3 pM[1].
Vixtimotamab (TandAb T564; 25 pM, 48 h) shows cytotoxicity against HL-60 and KG-1a cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Vixtimotamab Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: HL-60 and KG-1a cells
Concentration: 25 pM
Incubation Time: 48 h
Result: Showed cytotoxicity of 86.0±1.4% and 81.3±1.5% against HL-60 and KG-1a cells, respectively.
In Vivo

Vixtimotamab (TandAb T564; 0.1-10 μg/mouse, i.v.; 5 days) demonstrates dose-dependent tumor growth delay in a prophylactic HL-60 graft NOD/scid mouse model[1].
Vixtimotamab (TandAb T564; 50 μg/mouse/d, i.v.; 7 days) substantially inhibits tumor growth in an established HL-60 xenograft NOD/scid mouse model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 8-week-old NOD/scid female mice, weighing 20.7 ± 1.48 g, prophylactic HL-60 graft model[1]
Dosage: 0.1, 1, or 10 μg/mouse
Administration: Intravenous injection, on days 0, 1, 2, 3, and 4
Result: Demonstrated dose-dependent tumor growth delay.
Clinical Trial
SMILES

[Vixtimotamab]
Storage

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Purity & Documentation
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VixtimotamabAMV-564 TandAb T564AMV564AMV 564TandAb T564TandAb T 564TandAb T-564Othersacute myeloid leukemiaAMLHL-60KG-1aNOD/scidInhibitorinhibitorinhibit

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