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Vixtimotamab

(Synonyms: AMV-564; TandAb T564)
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Vixtimotamab (AMV-564; TandAb T564) is a bispecific tetravalent tandem diabody (TandAb) that targets human CD33 and human CD3 antigens. Vixtimotamab can be used for the research of acute myeloid leukemia (AML).

For research use only. We do not sell to patients.

  • Purity: 97.29%
  • CAS No.: 2243775-32-6
  • Molecular Weight:103.14 kDa
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Vixtimotamab
  • Experimental Validation Results for Vixtimotamab
  • Experimental Validation Results for Vixtimotamab
  • Experimental Validation Results for Vixtimotamab
  • Experimental Validation Results for Vixtimotamab
  • Vixtimotamab Chemical Structure
    Vixtimotamab Chemical Structure
CAS No.: 2243775-32-6
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Vixtimotamab Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    [V-kappa-VH-V-lambda-VH']-noncovalent dimer (tandem diabody)

  • 1/16

    Immobilized Vixtimotamab can bind Human CD3 epsilon/CD3e Protein (ECD, His Tag). The EC50 for this effect is 4.95 ng/mL.

  • 1/16

    Immobilized Vixtimotamab can bind Human Siglec-3/CD33 Protein (ECD, His Tag). The EC50 for this effect is 4.95 ng/mL.

  • 1/16

    Flow cytometric analysis of 1×106 Jurkat cells labelling CD3E (red) with Vixtimotamab (HY-P99958). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • 1/16

    Flow cytometric analysis of 1X106 THP-1 cells labeling CD33 with Vixtimotamab (HY-P99958, red). Cells were stained with the primary antibody at 1/200 dilution for an hour at 4℃. AF488-conjugated Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Vixtimotamab Chemical Structure
    1/16
  • Vixtimotamab
  • Immobilized Vixtimotamab can bind Human CD3 epsilon/CD3e Protein (ECD, His Tag). The EC50 for this effect is 4.95 ng/mL.
  • Immobilized Vixtimotamab can bind Human Siglec-3/CD33 Protein (ECD, His Tag). The EC50 for this effect is 4.95 ng/mL.
  • Flow cytometric analysis of 1×106 Jurkat cells labelling CD3E (red) with Vixtimotamab (HY-P99958). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
  • Flow cytometric analysis of 1X106 THP-1 cells labeling CD33 with Vixtimotamab (HY-P99958, red). Cells were stained with the primary antibody at 1/200 dilution for an hour at 4℃. AF488-conjugated Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
  • [V-kappa-VH-V-lambda-VH']-noncovalent dimer (tandem diabody)