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Referencia número: HY-183750

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BChE reactivator-1

BChE reactivator-1 is a human butyrylcholinesterase (BChE) activator and antidote, with a K_i value of 0.52 μM against human BChE. BChE reactivator-1 activates BChE inhibited by organophosphorus compounds, binds reversibly to native BChE, and restores cholinesterase activity in human whole blood. BChE reactivator-1 is applicable to research related to organophosphorus poisoning.

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No. CAS: 1482498-53-2
Fòrmula: C₁₈H₁₈BrN₃O
Peso molecular:372.26

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

BChE reactivator-1 Chemical Structure

No. CAS: 1482498-53-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
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Actividad biológica

Descripciòn

IC₅₀ & Target

^[1]

BChE

0.52 μM (Ki)

Ver todos los productos específicos de isoformas Cholinesterase (ChE) :

AChE
BChE

In Vitro

BChE reactivator-1 (Oxime 3) (0.1-3000 μM) potently inhibits human BChE with a K_i of 0.52 μM, exhibiting 40-fold higher binding selectivity for BChE than for human AChE^[1].
BChE reactivator-1 (100 μM; up to 24 h) is a potent reactivator of human BChE inhibited by cyclosarin, sarin, tabun, VX, and paraoxon, achieving the highest kobs values for cyclosarin- and sarin-inhibited BChE^[1].
BChE reactivator-1 (1, 10 μM) enables pseudo-catalytic detoxification of cyclosarin in human whole blood with supplemented BChE, restoring ~60% of total cholinesterase activity within 10 minutes for 30 μM cyclosarin at a 10 μM oxime concentration^[1].
BChE reactivator-1 (25-800 μM; 24 h) has an acceptable in vitro safety profile, with no cytotoxicity to human SH-SY5Y and HepG2 cells at concentrations < 100 μM, and IC₅₀ values of ≥ 400 μM (SH-SY5Y) and 248 μM (HepG2)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 1482498-53-2
Peso molecular 372.26
Fòrmula C₁₈H₁₈BrN₃O
SMILES

[H]/C(C1=[N+](C=CN1CC2=CC=CC=C2)CC3=CC=CC=C3)=N/O.[Br-]
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Kolić D, et al. N,N′-dibenzyl imidazolium oximes are potent reactivators of organophosphate-inhibited human butyrylcholinesterase. European Journal of Medicinal Chemistry. 2026;313:118895.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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