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Art. -Nr.: HY-183750

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BChE reactivator-1

BChE reactivator-1 is a human butyrylcholinesterase (BChE) activator and antidote, with a K_i value of 0.52 μM against human BChE. BChE reactivator-1 activates BChE inhibited by organophosphorus compounds, binds reversibly to native BChE, and restores cholinesterase activity in human whole blood. BChE reactivator-1 is applicable to research related to organophosphorus poisoning.

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CAS. Nr.: 1482498-53-2
Formel: C₁₈H₁₈BrN₃O
Molecular Weight:372.26

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

BChE reactivator-1 Chemical Structure

CAS. Nr.: 1482498-53-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

BChE

0.52 μM (Ki)

Alle Cholinesterase (ChE) Isoform-spezifische Produkte anzeigen :

AChE
BChE

In Vitro

BChE reactivator-1 (Oxime 3) (0.1-3000 μM) potently inhibits human BChE with a K_i of 0.52 μM, exhibiting 40-fold higher binding selectivity for BChE than for human AChE^[1].
BChE reactivator-1 (100 μM; up to 24 h) is a potent reactivator of human BChE inhibited by cyclosarin, sarin, tabun, VX, and paraoxon, achieving the highest kobs values for cyclosarin- and sarin-inhibited BChE^[1].
BChE reactivator-1 (1, 10 μM) enables pseudo-catalytic detoxification of cyclosarin in human whole blood with supplemented BChE, restoring ~60% of total cholinesterase activity within 10 minutes for 30 μM cyclosarin at a 10 μM oxime concentration^[1].
BChE reactivator-1 (25-800 μM; 24 h) has an acceptable in vitro safety profile, with no cytotoxicity to human SH-SY5Y and HepG2 cells at concentrations < 100 μM, and IC₅₀ values of ≥ 400 μM (SH-SY5Y) and 248 μM (HepG2)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 1482498-53-2
Molecular Weight 372.26
Formel C₁₈H₁₈BrN₃O
SMILES

[H]/C(C1=[N+](C=CN1CC2=CC=CC=C2)CC3=CC=CC=C3)=N/O.[Br-]
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Kolić D, et al. N,N′-dibenzyl imidazolium oximes are potent reactivators of organophosphate-inhibited human butyrylcholinesterase. European Journal of Medicinal Chemistry. 2026;313:118895.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise

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BChE reactivator-1

Alle Cholinesterase (ChE) Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

BChE reactivator-1 Related Classifications

HY-183750 Related Classifications