BI 703704

Art. -Nr.: HY-117962A: Data Sheet
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BI 703704 is a potent soluble guanylate cyclase (sGC) activator. BI 703704 inhibits the progression of diabetic nephropathy in the ZSF1 rat.

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BI 703704 Chemische Struktur

CAS. Nr. : 2740807-77-4

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Other Forms of BI 703704:

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Beschreibung

BI 703704 is a potent soluble guanylate cyclase (sGC) activator. BI 703704 inhibits the progression of diabetic nephropathy in the ZSF1 rat^[1].

In Vivo

BI 703704 (0.3-10 mg/kg; food intake; daily for 15 weeks) results in dose-dependent decreases in urinary protein excretion (UPE), and a dose-dependent increase in renal cGMP content^[1].
BI 703704 is effective in elevating renal cGMP levels in a dose-dependent manner and in slowing the progression of diabetic nephropathy in an oxidative stress milieu^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Fifty-eight male ZSF1 rats (12-13 weeks)^[1]
Dosage:	0.3, 1, 3, or 10 mg/kg
Administration:	Food intake; daily for 15 weeks
Result:	Resulted in dose-dependent decreases in urinary protein excretion (UPE), and a dose-dependent increase in renal cGMP content.

Molekulargewicht

559.72

Formel

C₃₂H₃₇N₃O₄S

CAS. Nr.

2740807-77-4

Appearance

Solid

Color

White to off-white

SMILES

CC1=CC(C2=CSC(N3C[C@H](CC4)[C@@H](C(O)=O)[C@H]4C3)=N2)=C(OCC5=CC=C(C(N6CCCCC6)=O)C=C5C)C=C1

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Data Sheet (270 KB) SDS (252 KB) Handling Instructions (2659 KB)

Verweise

[1]. Boustany-Kari CM, et al. A Soluble Guanylate Cyclase Activator Inhibits the Progression of Diabetic Nephropathy in the ZSF1 Rat. J Pharmacol Exp Ther. 2016 Mar;356(3):712-9. [Content Brief]

BI 703704 Related Classifications

Metabolic Disease

Molaritätsrechner
Verdünnungsrechner

Die Formel zur Berechnung von Molaritäten

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Diese Gleichung wird häufig abgekürzt als: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BI 7037042740807-77-4BI703704BI-703704Guanylate CyclasediabeticnephropathyZSF1ratcGMPtype2diabetesoxidativestressmilieuInhibitorinhibitorinhibit

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BI 703704

Other Forms of BI 703704:

BI 703704 Related Antibodies

Spezialitätsempfehlungen

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BI 703704 Related Classifications

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