2. GPCR/G Protein
  3. Bradykinin Receptor
  4. BKM-570

BKM-570 is a nonpeptide bradykinin antagonist with anticancer effects. BKM-570 can be used in the study of lung cancer, prostate cancer and ovarian cancer.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

BKM-570

BKM-570 Chemische Struktur

CAS. Nr. : 259885-54-6

Größe Verfügbarkeit
50 mg   Angebot einholen  
100 mg   Angebot einholen  
250 mg   Angebot einholen  

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

This product is a controlled substance and not for sale in your territory.

BKM-570 Related Antibodies

Top Publications Citing Use of Products

Alle Bradykinin Receptor Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen
Bradykinin B1 Receptor (B1R) Bradykinin B2 Receptor (B2R)

  • Biologische Aktivität

  • Reinheit & Dokumentation

  • Verweise

  • Kundenbewertung

Beschreibung

BKM-570 is a nonpeptide bradykinin antagonist with anticancer effects. BKM-570 can be used in the study of lung cancer, prostate cancer and ovarian cancer[1].

Cellular Effect
Cell Line Type Value Description References
C6 IC50
4 μM
Compound: BKM-570
Cytotoxicity against rat C6 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against rat C6 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 25012567]
Cancer cell lines IC50
1.8 μM
Compound: BKM-570
Cytotoxicity against human Small cell lung cancer cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human Small cell lung cancer cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 25012567]
Granta IC50
63.3 μM
Compound: BKM-570
Cytotoxicity against human Granta cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human Granta cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 25012567]
HEK293 IC50
3.8 μM
Compound: BKM-570
Cytotoxicity against HEK293 cells overexpressing CHI3L1 gene assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against HEK293 cells overexpressing CHI3L1 gene assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 25012567]
JeKo-1 IC50
49.3 μM
Compound: BKM-570
Cytotoxicity against human Jeko cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human Jeko cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 25012567]
U-373MG ATCC IC50
3.3 μM
Compound: BKM-570
Cytotoxicity against human U373 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human U373 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 25012567]
Molekulargewicht

698.55

Formel

C34H34Cl2F5N3O3
CAS. Nr.
SMILES

O=C([C@@H](NC(/C=C/C1=C(C(F)=C(C(F)=C1F)F)F)=O)CC2=CC=C(C=C2)OCC3=C(C=CC=C3Cl)Cl)NC4CC(C)(C)NC(C)(C)C4
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

BKM-570 Related Classifications

  • Molaritätsrechner

  • Verdünnungsrechner

Die Formel zur Berechnung von Molaritäten

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)

Diese Gleichung wird häufig abgekürzt als: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BKM-570259885-54-6BKM570BKM 570Bradykinin Receptorbradykinin antagonistlung cancerprostate cancer and ovarian cancerInhibitorinhibitorinhibit

Ihre kürzlich angesehenen Produkte:

Online-Anfrage

Your information is safe with us. * Required Fields.

Produktname

  

Requested Quantity *

Name des Antragstellers *

 

Anrede

E-Mail-Addresse *

 

Telefonnummer *

Department

 

Name der Organisation *

City

Bundesland

Country or Region *

      

Bemerkungen

Massenanfrage

Inquiry Information

Produktname:
BKM-570
Art. -Nr.:
HY-123560
Menge:
MCE Japan Authorized Agent:

Kundenbewertung

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Produktname

  

Lot #

Name des Antragstellers *

 

E-Mail-Addresse *

Telefonnummer

 

Department *

Name der Organisation *

 

Country or Region *

Bemerkungen

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.