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Cat. No.: HY-112744

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BMS-856

BMS-856 is a 17β-HSD3 inhibitor. BMS-856 inhibits enzymatic activity of 17β-HSD3, with IC₅₀s of 60 and 300 nM respectively in the enzyme and whole cell assays.

For research use only. We do not sell to patients.

CAS No.: 863382-83-6
Formula: C₂₉H₂₅ClN₂O₅
Molecular Weight:516.97

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

BMS-856 Chemical Structure

CAS No.: 863382-83-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

BMS-856 is a 17β-HSD3 inhibitor. BMS-856 inhibits enzymatic activity of 17β-HSD3, with IC₅₀s of 60 and 300 nM respectively in the enzyme and whole cell assays^[1].

All 17β-HSD Isoforms :

17β-HSD5/AKR1C3

Chemical Information

CAS No. 863382-83-6
Molecular Weight 516.97
Formula C₂₉H₂₅ClN₂O₅
SMILES

O=C(C1=CC=C(C(Cl)=C1)O)NC2=CC=C(C=C2C(NCCC3=C(OC)C=CC=C3)=O)OC4=CC=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Day JM, et al. Design and validation of specific inhibitors of 17beta-hydroxysteroid dehydrogenases for therapeutic application in breast and prostate cancer, and in endometriosis. Endocr Relat Cancer. 2008 Sep;15(3):665-92. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
Chemical Information
Purity & Documentation
References

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BMS-856

All 17β-HSD Isoforms