Boc-Aminooxy-PEG3-azide

Name: Boc-Aminooxy-PEG3-azide
Brand: MedChemExpress
SKU: HY-140432
Rating: 4.5 (0 reviews)

Cat. No.: HY-140432: Fiche technique Instruction de manipulation
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Boc-Aminooxy-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Boc-Aminooxy-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

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Boc-Aminooxy-PEG3-azide Chemical Structure

CAS No. : 1235514-15-4

Size	Stock	Quantité
25 mg	Obtenir un devis 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
50 mg	Obtenir un devis 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
100 mg	Obtenir un devis 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
250 mg	Obtenir un devis 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
1 g	Obtenir un devis 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
5 g	Obtenir un devis
10 g	Obtenir un devis

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Recommandations en vedette

•Related Small Molecules:

•Related Proteins:

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PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

Activité biologique
Pureté et documentation
Références
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Description

Boc-Aminooxy-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs^[1]. Boc-Aminooxy-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC₅₀ & Target

PEGs	Alkyl/ether

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Masse moléculaire

334.37

Formule

C₁₃H₂₆N₄O₆

CAS No.

1235514-15-4

SMILES

O=C(OC(C)(C)C)NOCCOCCOCCOCCN=[N+]=[N-]

Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Zhao B, et al. Protein Engineering in the Ubiquitin System: Tools for Discovery and Beyond. Pharmacol Rev. 2020 Apr;72(2):380-413. [Content Brief]