d-KLA Peptide
Based on 1 Customer Validation
d-KLA Peptide (D-(KLAKLAK)2), KLA peptide (HY-P5345) isomer, is a pro-apoptosis peptide. d-KLA Peptide can specifically target mitochondria and induce apoptosis by destroying the mitochondrial membrane. d-KLA Peptide increases caspase 3/7 activity, exerts proapoptotic activity and enhances antitumor efficacy in mouse melanoma models.
For research use only. We do not sell to patients.
- Purity: 99.33%
- CAS No.: 286380-05-0
- Formula: C72H138N20O15
- Molecular Weight:1523.99
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Caspase Isoforms
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Biological Activity
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Caspase-3 |
Caspase-7 |
d-KLA Peptide (400 μM) kills 50% of eukaryotic cells in the monolayer[1].
d-KLA Peptide induces mitochondrial swelling in a cell-free system with an ED50 of 0.44 μM[1].
d-KLA Peptide induces mitochondrial membrane potential loss in a cell-free system with an ED50 of 0.4 μM[1].
d-KLA Peptide (1.5 μM in 1 μM ODN; 24 h) can form liposomes, which can reduce the viability of B16 (F10) mouse melanoma cells and enhance caspase 3/7 activity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6 (male, initial weight 24.4 g, subcutaneous B16(F10) melanoma model)[1]
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Dosage:1.52 µg with G3139 (4 µg) in cationic liposome
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Administration:intratumoral; twice daily for 2 doses; intratumoral
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Result:Reduced tumor volume increase to 186% by day 4 post-treatment, compared to 470% for untreated controls.
Achieved a tumor growth inhibition (TGI) of 60%.
Induced significant apoptosis in tumor tissues as evidenced by bright green staining of apoptotic nuclei in TUNEL assays.
Chemical Information
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CAS No. 286380-05-0
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Appearance Solid
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Molecular Weight 1523.99
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Formula C72H138N20O15
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Color White to off-white
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Synonyms
D-(KLAKLAK)2
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Sequence
d-{Lys-Leu-Ala-Lys-Leu-Ala-Lys-Lys-Leu-Ala-Lys-Leu-Ala-Lys}
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Sequence Shortening
d-{KLAKLAKKLAKLAK}
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H2O : 25 mg/mL (16.40 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| H2O | 1 mM | 0.6562 mL | 3.2809 mL | 6.5617 mL | 16.4043 mL |
| 5 mM | 0.1312 mL | 0.6562 mL | 1.3123 mL | 3.2809 mL | |
| 10 mM | 0.0656 mL | 0.3281 mL | 0.6562 mL | 1.6404 mL | |
| 15 mM | 0.0437 mL | 0.2187 mL | 0.4374 mL | 1.0936 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
d-KLA Peptide Related Classifications
HY-P10285 Related Classifications
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- d-KLA Peptide
- 286380-05-0
- D-(KLAKLAK)2
- Apoptosis
- Mitochondrial Metabolism
- Caspase
- cancer cells
- prokaryotic cytoplasmic membranes
- mouse melanoma models
- caspase 3/7
- mitochondrial membranes
- B16(F10) mouse melanoma cells
- mitochondrial-dependent apoptosis
- melanoma
- apoptosis
- eukaryotic plasma membranes
- Inhibitor
- inhibitor
- inhibit