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CYB561 - cytochrome b561 Gene

Also Known as FRRS2; ORTHYP2; CYB561A1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1534

About CYB561

Cytogenetic location: 17q23.3 Genomic coordinates (GRCh38): 17:63,432,304-63,446,639 (from NCBI)

This gene has 21 transcripts (splice variants), 199 orthologues, 2 paralogues and is associated with 1 phenotype. Broad expression in adrenal (RPKM 53.1), prostate (RPKM 31.9) and 23 other tissues.

Summary

Predicted to enable transmembrane monodehydroascorbate reductase activity. Predicted to be involved in ascorbate homeostasis. Predicted to be located in chromaffin granule membrane. Predicted to be active in lysosomal membrane. [provided by Alliance of Genome Resources, Apr 2022]

CYB561 Products (4)

mRNA	Protein	Name
NM_001017916.2	NP_001017916.1	transmembrane ascorbate-dependent reductase CYB561 isoform 1
NM_001017917.2	NP_001017917.1	transmembrane ascorbate-dependent reductase CYB561 isoform 1
NM_001330421.2	NP_001317350.1	transmembrane ascorbate-dependent reductase CYB561 isoform 2
NM_001915.4	NP_001906.3	transmembrane ascorbate-dependent reductase CYB561 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Références	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CYB561 Protein Structure

Cytochrom_B561

0
100
200
251 a.a.

Protein Preferred Names	Protein Names
transmembrane ascorbate-dependent reductase CYB561	cytochrome b-561

CYB561 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	CYB561	P49447	SLC38A7	Homo sapiens	Q9NVC3	Validated Y2H	32296183
Intra	CYB561	P49447	SLC38A7	Homo sapiens	Q9NVC3	Y2H Array	32296183
Intra	CYB561	P49447	SLC38A7	Homo sapiens	Q9NVC3	Y2H Prey Pooling	32296183
Intra	CYB561	P49447	TMEM242	Homo sapiens	Q9NWH2	Validated Y2H	32296183
Intra	CYB561	P49447	SYNJ2BP	Homo sapiens	P57105	Validated Y2H	32296183
Intra	CYB561	P49447	GGT7	Homo sapiens	Q9UJ14	Y2H Prey Pooling	32296183
Intra	CYB561	P49447	GGT7	Homo sapiens	Q9UJ14	Validated Y2H	32296183
Intra	CYB561	P49447	GGT7	Homo sapiens	Q9UJ14	Y2H Array	32296183
Intra	CYB561	P49447	VAPA	Homo sapiens	Q9P0L0	Validated Y2H	32296183
Intra	CYB561	P49447	TMEM128	Homo sapiens	Q5BJH2-2	Validated Y2H	32296183
Intra	CYB561	P49447	ORMDL2	Homo sapiens	Q53FV1	Validated Y2H	32296183
Intra	CYB561	P49447	GPX8	Homo sapiens	Q8TED1	Y2H Array	32296183
Intra	CYB561	P49447	GPX8	Homo sapiens	Q8TED1	Y2H Prey Pooling	32296183
Intra	CYB561	P49447	GPX8	Homo sapiens	Q8TED1	Validated Y2H	32296183
Intra	CYB561	P49447	TMEM179B	Homo sapiens	Q7Z7N9	Y2H Prey Pooling	32296183
Intra	CYB561	P49447	TMEM179B	Homo sapiens	Q7Z7N9	Validated Y2H	32296183
Intra	CYB561	P49447	TMEM179B	Homo sapiens	Q7Z7N9	Y2H Array	32296183
Intra	CYB561	P49447	TMPPE	Homo sapiens	Q6ZT21	Validated Y2H	32296183
Intra	CYB561	P49447	LPAR3	Homo sapiens	Q9UBY5	Validated Y2H	32296183
Intra	CYB561	P49447	ANKRD46	Homo sapiens	Q86W74-2	Validated Y2H	32296183
Intra	CYB561	P49447	OPRM1	Homo sapiens	P35372-10	Y2H Prey Pooling	32296183
Intra	CYB561	P49447	OPRM1	Homo sapiens	P35372-10	Y2H Array	32296183
Intra	CYB561	P49447	SLC39A2	Homo sapiens	Q9NP94	Validated Y2H	32296183
Intra	CYB561	P49447	SLC39A2	Homo sapiens	Q9NP94	Y2H Array	32296183
Intra	CYB561	P49447	SLC39A2	Homo sapiens	Q9NP94	Y2H Prey Pooling	32296183
Intra	CYB561	P49447	ZDHHC7	Homo sapiens	Q9NXF8-2	Y2H Prey Pooling	32296183
Intra	CYB561	P49447	ZDHHC7	Homo sapiens	Q9NXF8-2	Validated Y2H	32296183
Intra	CYB561	P49447	ZDHHC7	Homo sapiens	Q9NXF8-2	Y2H Array	32296183
Intra	CYB561	P49447	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	CYB561	P49447	AQP6	Homo sapiens	Q13520	Validated Y2H	32296183
Intra	CYB561	P49447	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	CYB561	P49447	GPR152	Homo sapiens	Q8TDT2	Y2H Array	32296183
Intra	CYB561	P49447	GPR152	Homo sapiens	Q8TDT2	Y2H Prey Pooling	32296183
Intra	CYB561	P49447	GPR152	Homo sapiens	Q8TDT2	Validated Y2H	32296183
Intra	CYB561	P49447	TM4SF18	Homo sapiens	Q96CE8	Y2H Prey Pooling	32296183
Intra	CYB561	P49447	TM4SF18	Homo sapiens	Q96CE8	Validated Y2H	32296183
Intra	CYB561	P49447	TM4SF18	Homo sapiens	Q96CE8	Y2H Array	32296183
Intra	CYB561	P49447	STX3	Homo sapiens	Q13277	Validated Y2H	32296183
Intra	CYB561	P49447	REEP6	Homo sapiens	Q96HR9-2	Validated Y2H	32296183
Intra	CYB561	P49447	TREX1	Homo sapiens	Q9NSU2-1	Validated Y2H	32296183
Intra	CYB561	P49447	SSMEM1	Homo sapiens	Q8WWF3	Y2H Prey Pooling	32296183
Intra	CYB561	P49447	SSMEM1	Homo sapiens	Q8WWF3	Validated Y2H	32296183
Intra	CYB561	P49447	SSMEM1	Homo sapiens	Q8WWF3	Y2H Array	32296183
Intra	CYB561	P49447	SLC35C2	Homo sapiens	Q9NQQ7-3	Validated Y2H	32296183
Intra	CYB561	P49447	SLC35C2	Homo sapiens	Q9NQQ7-3	Y2H Array	32296183
Intra	CYB561	P49447	SLC35C2	Homo sapiens	Q9NQQ7-3	Y2H Prey Pooling	32296183
Intra	CYB561	P49447	EFNA5	Homo sapiens	P52803	Y2H Prey Pooling	32296183
Intra	CYB561	P49447	EFNA5	Homo sapiens	P52803	Validated Y2H	32296183
Intra	CYB561	P49447	EFNA5	Homo sapiens	P52803	Y2H Array	32296183
Intra	CYB561	P49447	CLDN9	Homo sapiens	O95484	Y2H Array	32296183
Intra	CYB561	P49447	CLDN9	Homo sapiens	O95484	Y2H Prey Pooling	32296183
Intra	CYB561	P49447	BEST2	Homo sapiens	Q8NFU1	Validated Y2H	32296183
Intra	CYB561	P49447	BEST2	Homo sapiens	Q8NFU1	Y2H Array	32296183
Intra	CYB561	P49447	BEST2	Homo sapiens	Q8NFU1	Y2H Prey Pooling	32296183
Intra	CYB561	P49447	EHHADH	Homo sapiens	Q08426	Validated Y2H	32296183
Intra	CYB561	P49447	CMTM2	Homo sapiens	Q8TAZ6	Y2H Prey Pooling	32296183
Intra	CYB561	P49447	CMTM2	Homo sapiens	Q8TAZ6	Validated Y2H	32296183
Intra	CYB561	P49447	CMTM2	Homo sapiens	Q8TAZ6	Y2H Array	32296183
Intra	CYB561	P49447	LHFPL5	Homo sapiens	Q8TAF8	Validated Y2H	32296183
Intra	CYB561	P49447	LHFPL5	Homo sapiens	Q8TAF8	Y2H Prey Pooling	32296183
Intra	CYB561	P49447	LHFPL5	Homo sapiens	Q8TAF8	Y2H Array	32296183
Intra	CYB561	P49447	EBP	Homo sapiens	Q15125	Y2H Array	32296183
Intra	CYB561	P49447	EBP	Homo sapiens	Q15125	Validated Y2H	32296183
Intra	CYB561	P49447	EBP	Homo sapiens	Q15125	Y2H Prey Pooling	32296183
Intra	CYB561	P49447	DARS2	Homo sapiens	Q6PI48	Y2H Prey Pooling	32296183
Intra	CYB561	P49447	DARS2	Homo sapiens	Q6PI48	Validated Y2H	32296183
Intra	CYB561	P49447	DARS2	Homo sapiens	Q6PI48	Y2H Array	32296183
Intra	CYB561	P49447	SLC19A3	Homo sapiens	Q9BZV2	Y2H Prey Pooling	32296183
Intra	CYB561	P49447	SLC19A3	Homo sapiens	Q9BZV2	Validated Y2H	32296183
Intra	CYB561	P49447	SLC19A3	Homo sapiens	Q9BZV2	Y2H Array	32296183
Intra	CYB561	P49447	BNIP1	Homo sapiens	Q12981	Validated Y2H	32296183
Intra	CYB561	P49447	EDA	Homo sapiens	Q92838	Y2H Array	32296183
Intra	CYB561	P49447	EDA	Homo sapiens	Q92838	Validated Y2H	25416956
Intra	CYB561	P49447	EDA	Homo sapiens	Q92838	Y2H Prey Pooling	32296183
Intra	CYB561	P49447	EDA	Homo sapiens	Q92838	Validated Y2H	32296183
Intra	CYB561	P49447	EDA	Homo sapiens	Q92838	Y2H Array	25416956
Intra	CYB561	P49447	PLP2	Homo sapiens	Q04941	Validated Y2H	32296183
Intra	CYB561	P49447	GIMAP5	Homo sapiens	Q96F15	Validated Y2H	32296183
Intra	CYB561	P49447	TMEM65	Homo sapiens	Q6PI78	Validated Y2H	32296183
Intra	CYB561	P49447	BIK	Homo sapiens	Q13323	Y2H Prey Pooling	32296183
Intra	CYB561	P49447	BIK	Homo sapiens	Q13323	Validated Y2H	32296183
Intra	CYB561	P49447	BIK	Homo sapiens	Q13323	Y2H Array	32296183
Intra	CYB561	P49447	ERG28	Homo sapiens	Q9UKR5	Validated Y2H	32296183
Intra	CYB561	P49447	FKBP8	Homo sapiens	Q14318	Validated Y2H	32296183
Intra	CYB561	P49447	SLC39A1	Homo sapiens	Q9NY26	Validated Y2H	32296183
Intra	CYB561	P49447	SLC39A1	Homo sapiens	Q9NY26	Y2H Array	32296183
Intra	CYB561	P49447	SLC39A1	Homo sapiens	Q9NY26	Y2H Prey Pooling	32296183
Intra	CYB561	P49447	SERP2	Homo sapiens	Q8N6R1	Validated Y2H	32296183
Intra	CYB561	P49447	CD79A	Homo sapiens	P11912	Y2H Prey Pooling	32296183
Intra	CYB561	P49447	CD79A	Homo sapiens	P11912	Y2H Array	32296183
Intra	CYB561	P49447	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
Intra	CYB561	P49447	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183
Intra	CYB561	P49447	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	CYB561	P49447	TMEM14B	Homo sapiens	Q9NUH8	Y2H Array	32296183
Intra	CYB561	P49447	TMEM14B	Homo sapiens	Q9NUH8	Validated Y2H	32296183
Intra	CYB561	P49447	TMEM14B	Homo sapiens	Q9NUH8	Y2H Prey Pooling	32296183
Intra	CYB561	P49447	SEC22A	Homo sapiens	Q96IW7	Validated Y2H	32296183
Intra	CYB561	P49447	UBE2J1	Homo sapiens	Q9Y385	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Orthostatic Hypotension 2	ORTHYP2
Dopamine Beta-Hydroxylase Deficiency	Noradrenaline Deficiency Norepinephrine Deficiency Dopamine Beta Hydroxylase Deficiency Congenital Dopamine Beta-Hydroxylase Deficiency Dopamine Beta-Hydroxylase Deficiency, Congenital Dopamine Β-Hydroxylase Dbh Deficiency
Glycogen Storage Disease Ixd	GSD9D Gsd Ixd Muscle Phosphorylase Kinase Deficiency Muscle Glycogenosis Glycogen Storage Disease Due To Muscle Phosphorylase Kinase Deficiency Glycogen Storage Disease Type 9d Glycogen Storage Disease Type 9e Glycogen Storage Disease Type Ixd Glycogen Storage Disease Type Ixe Glycogenosis Due To Muscle Phosphorylase Kinase Deficiency Glycogenosis Type 9d Glycogenosis Type 9e Glycogenosis Type Ixd Glycogenosis Type Ixe Gsd Due To Muscle Phosphorylase Kinase Deficiency Gsd Type 9d Gsd Type 9e Gsd Type Ixd Gsd Type Ixe Muscle Glycogenosis, X-Linked X-Linked Muscke Glycogenosis Glycogen Storage Disease 9d X-Linked Muscle Glycogenosis Storage Disease, Glycogen, Type Ixd
Corticosteroid-Binding Globulin Deficiency	CBG DEFICIENCY Transcortin Deficiency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS03416	CYB561 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CYB561	MGD	MGI:103253
Rattus norvegicus	CYB561	RGD	RGD:1310987
Macaca mulatta	CYB561	VGNC	VGNC:71574
Canis familiaris	CYB561	VGNC	VGNC:49089
Felis catus	CYB561	VGNC	VGNC:61306
Bos taurus	CYB561	VGNC	VGNC:50257
Others	CYB561	NCBI