SLC39A1 - solute carrier family 39 member 1 Gene

Also Known as ZIP1; ZIRTL

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 27173

About SLC39A1

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:153,959,110-153,968,184 (from NCBI)

This gene has 10 transcripts (splice variants), 190 orthologues and 2 paralogues. Ubiquitous expression in placenta (RPKM 41.2), lung (RPKM 24.3) and 25 other tissues.

Summary

This gene encodes a member of the zinc-iron permease family. The encoded protein is localized to the cell membrane and acts as a zinc uptake transporter. This gene has been linked to prostate Cancer, breast Cancer, and Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

SLC39A1 Products (6)

mRNA	Protein	Name
NM_001271957.2	NP_001258886.1	zinc transporter ZIP1 isoform a
NM_001271958.2	NP_001258887.1	zinc transporter ZIP1 isoform a
NM_001271959.2	NP_001258888.1	zinc transporter ZIP1 isoform a
NM_001271960.2	NP_001258889.1	zinc transporter ZIP1 isoform a
NM_001271961.2	NP_001258890.1	zinc transporter ZIP1 isoform b
NM_014437.5	NP_055252.2	zinc transporter ZIP1 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA
enables zinc ion transmembrane transporter activity	IDA IDA: Inferred from direct assay	11301334	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in zinc ion transmembrane transport	IDA IDA: Inferred from direct assay	11301334	GOA
involved in zinc ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	11301334	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	11301334	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC39A1 Protein Structure

Zip

0
100
200
300
324 a.a.

Protein Preferred Names	Protein Names
zinc transporter ZIP1	ZRT/IRT-like protein 1

SLC39A1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SLC39A1	Q9NY26	NME2P1	Homo sapiens	O60361	Anti Tag CoIP	33961781
Intra	SLC39A1	Q9NY26	NME2P1	Homo sapiens	O60361	Anti Tag CoIP	28514442
Intra	SLC39A1	Q9NY26	OPTN	Homo sapiens	Q96CV9	Y2H Pooling	32814053
Intra	SLC39A1	Q9NY26	OPTN	Homo sapiens	Q96CV9	Validated Y2H	32814053
Intra	SLC39A1	Q9NY26	OPTN	Homo sapiens	Q96CV9	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Acrodermatitis Enteropathica, Zinc-Deficiency Type	Acrodermatitis Enteropathica AEZ Enteropathica Brandt Syndrome Ae Acrodermatitis Enteropathica Zinc Deficiency Type Danbolt-Cross Syndrome Acrodermatitis Enteropathica, Zinc Deficiency Type Inherited Zinc Deficiency Acrodermatitis Enteropathica, Zinc Deficiency Danbolt-Closs Syndrome Primary Zinc Malabsorption Syndrome
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Hemochromatosis, Type 1	Hemochromatosis Hemochromatosis Type 1 Hereditary Hemochromatosis Hh HFE1 Hfe Hemochromatosis, Modifier Of Symptomatic Form Of Classic Hemochromatosis Symptomatic Form Of Hemochromatosis Type 1 Symptomatic Form Of Hfe-Related Hereditary Hemochromatosis Haemochromatosis Iron Storage Disorder Bronze Diabetes Hereditary Haemochromatosis Hlah Hfe Hemochromatosis, Hereditary Diabetes Bronze Classic Hemochromatosis Hfe-Associated Hereditary Hemochromatosis Hemochromatosis Classic Bronzed Cirrhosis Familial Hemochromatosis Genetic Hemochromatosis Hc Pigmentary Cirrhosis Primary Hemochromatosis Troisier-Hanot-Chauffard Syndrome Von Recklenhausen-Applebaum Disease Hemochromatosis 1 Primary Hereditary Hemochromatosis Bronze Cirrhosis
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13228	SLC39A1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16233	Slc39a1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS13244	Slc40a1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS13245	SLC40A1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SLC39A1	RGD	RGD:1305241
Felis catus	SLC39A1	VGNC	VGNC:65353
Macaca mulatta	SLC39A1	VGNC	VGNC:100141
Canis familiaris	SLC39A1	VGNC	VGNC:46400
Bos taurus	SLC39A1	VGNC	VGNC:34857
Mus musculus	SLC39A1	MGD	MGI:1353474
Others	SLC39A1	NCBI