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Cat. No.: HY-P11746

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GPLGIAGQC

GPLGIAGQC is an MMP2-cleavable peptide. In nanoparticle-drug conjugation systems, GPLGIAGQC is cleaved by MMP2 between the glycine and isoleucine residues. After MMP2-mediated hydrolysis of GPLGIAGQC, the Fc fragment is exposed on the surface of nanoparticles.

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CAS No.: 1423719-70-3
Formule: C₃₄H₅₈N₁₀O₁₁S
Masse moléculaire:814.95

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Please store the product under the recommended conditions in the Certificate of Analysis.

Synthèse personnalisée de peptides

GPLGIAGQC Chemical Structure

CAS No.: 1423719-70-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Voir tous les produits spécifiques à Isoform MMP :

In Vitro

The GPLGIAGQC peptide (10-40 nM MMP2; 24 h) acts as an MMP2-cleavable linker in AP-PP-DOX nanoparticles, enabling sustained, MMP2-dependent release of DOX with minimal leakage in MMP2-deficient conditions^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1423719-70-3
Masse moléculaire 814.95
Formule C₃₄H₅₈N₁₀O₁₁S
Sequence

Gly-Pro-Leu-Gly-Ile-Ala-Gly-Gln-Cys
Sequence Shortening

GPLGIAGQC
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Wang MZ, et al. A Nano Drug Delivery System Based on Angelica sinensis Polysaccharide for Combination of Chemotherapy and Immunotherapy. Molecules. 2020 Jul 7;25(13):3096. [Content Brief]

[2]. Liu XY, et al. A nano-innate immune system activator for cancer therapy in a 4T1 tumor-bearing mouse model. J Nanobiotechnology. 2022 Jan 29;20(1):54. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références

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GPLGIAGQC

Voir tous les produits spécifiques à Isoform MMP

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

GPLGIAGQC Related Classifications

HY-P11746 Related Classifications