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Cat. No.: HY-146750

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HDAC-IN-37

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

HDAC-IN-37 is a potent HDAC inhibitor with IC₅₀s of 0.0551 μM, 1.24 μM, 0.948 μM and 34.2 μM for HDAC1, HDAC3, HDAC8 and HDAC6, respectively. HDAC-IN-37 induces histone acetylation in a slow-off manner. HDAC-IN-37 prevents cell transition from G1 phase to S phase and induces early cell apoptosis.

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CAS No.: 2766466-56-0
Formule: C₂₃H₂₄ClN₇O
Masse moléculaire:449.94

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

HDAC-IN-37 Chemical Structure

CAS No.: 2766466-56-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Publications (1)
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target^[1]

HDAC1

55.1 nM (IC₅₀)

HDAC3

1.24 μM (IC₅₀)

HDAC8

0.948 μM (IC₅₀)

HDAC6

34.2 μM (IC₅₀)

Voir tous les produits spécifiques à Isoform HDAC :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	1.65 μM Compound: 9d	Antiproliferative activity against human A549 cells measured after 48 hrs by MTT assay Antiproliferative activity against human A549 cells measured after 48 hrs by MTT assay	[PMID: 35041998]
HCT-116	IC₅₀	0.5 μM Compound: 9d	Antiproliferative activity against human HCT-116 cells measured after 48 hrs by MTT assay Antiproliferative activity against human HCT-116 cells measured after 48 hrs by MTT assay	[PMID: 35041998]
HepG2	IC₅₀	1.29 μM Compound: 9d	Antiproliferative activity against human HepG2 cells measured after 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells measured after 48 hrs by MTT assay	[PMID: 35041998]
K562	IC₅₀	0.12 μM Compound: 9d	Antiproliferative activity against human K562 cells measured after 48 hrs by MTT assay Antiproliferative activity against human K562 cells measured after 48 hrs by MTT assay	[PMID: 35041998]
MDA-MB-231	IC₅₀	0.38 μM Compound: 9d	Antiproliferative activity against human MDA-MB-231 cells measured after 48 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells measured after 48 hrs by MTT assay	[PMID: 35041998]
SGC-7901	IC₅₀	1.52 μM Compound: 9d	Antiproliferative activity against human SGC-7901 cells measured after 48 hrs by MTT assay Antiproliferative activity against human SGC-7901 cells measured after 48 hrs by MTT assay	[PMID: 35041998]

In Vitro

HDAC-IN-37 (compound 9d) exhibits the potent antiproliferative activities on the HCT116, MDA-MB-231, K562 cell lines at IC₅₀s of 0.50, 0.38, 0.12 μM, respectively^[1].
HDAC-IN-37 (0 - 10 μM; 24 hours) significantly induces the accumulation of acetylated histones at H3K9 and H4K5 in HCT-116 cells^[1].
HDAC-IN-37 (0 - 10 μM; 24 hours) induces cell apoptosis in HCT-116 cells by 35.22%, 58.34, 80.7% at 0.5, 1, 5 μM, mainly occurring in early apoptosis^[1].
HDAC-IN-37 (0 - 10 μM; 6, 12, 24 hours) causes G0/G1 phase arrest of HCT-116 cells in a time-dependent manner, effectively preventing cell cycle progression^[1].
HDAC-IN-37 (0, 0.1, 0.5, 1, 5 and 10 μM; 0, 6, 12, 24, 36, 48 hours) down-regulates the levels of CDK2, Cyclin D1 and the up-regulates P21 with dose- and time-dependent manners in HCT-116 cells, and decreases Bcl-2 of Bcl-2 family in dose- and time-dependent manners^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay

Cell Line:

HCT-116, MDA-MB-231, HepG2, A549, SGC7901 and K562^[1]
Concentration:

0-10 μM
Incubation Time:

48 hours
Result:

Exhibited the potent antiproliferative activities on the HCT116, MDA-MB-231, K562 cell lines at IC₅₀ of 0.50, 0.38, 0.12 μM, respectively.

Western Blot Analysis

Cell Line:

HCT-116^[1]
Concentration:

0, 0.1, 0.5, 1, 5 and 10 μM
Incubation Time:

24 hours
Result:

Significantly induced the accumulation of acetylated histones at H3K9 and H4K5 in HCT-116 cells.

Apoptosis Analysis

Cell Line:

HCT-116^[1]
Concentration:

0.1, 0.5, 1, 5 and 10 μM
Incubation Time:

24 hours
Result:

Induced cell apoptosis in HCT-116 cells by 35.22%, 58.34, 80.7% at 0.5, 1, 5 μM, mainly occurring in early apoptosis.

Cell Cycle Analysis

Cell Line:

HCT-116^[1]
Concentration:

0.1, 0.5, 1, 5 and 10 μM
Incubation Time:

0, 6, 12 and 24 hours
Result:

Caused G0/G1 phase arrest of HCT-116 cells in a time-dependent manner, effectively preventing cell cycle progression.

Chemical Information

CAS No. 2766466-56-0
Masse moléculaire 449.94
Formule C₂₃H₂₄ClN₇O
SMILES

CCCCNC1=C2N=CN(C2=NC(Cl)=N1)CC3=CC=C(C=C3)C(NC4=CC=CC=C4N)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Journal Impact Factor

Int J Parasitol Drugs Drug Resist

2026 May 17;31:100649.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Mao PT, He WB, Mai X, et al. Synthesis and biological evaluation of aminobenzamides containing purine moiety as class I histone deacetylases inhibitors. Bioorg Med Chem. [Content Brief]

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Keywords

HDAC-IN-37

1 Cited Publications

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Activité biologique
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- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (1)
Pureté et documentation
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HDAC-IN-37

Publications Citing Use of MedChemExpress (MCE) HDAC-IN-37

Voir tous les produits spécifiques à Isoform HDAC

Activité biologique

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Publications (1)

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Help & FAQs

HDAC-IN-37 Related Classifications

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