LY 181984
Based on 1 Customer Validation
LY181984 is a compound in a series of orally active diarylsulfonylureas. LY181984 shows antitumor activity.
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- Pureté: 95.0%
- CAS No.: 3955-50-8
- Formule: C14H13ClN2O3S
- Masse moléculaire:324.78
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Stockage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CCRF-CEM | IC50 |
8.9 μg/mL
Compound: 17 (LY-181984)
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Concentration required to inhibit growth of CCRF-CEM cells in culture for 72 hr to 50% of control growth
Concentration required to inhibit growth of CCRF-CEM cells in culture for 72 hr to 50% of control growth
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[PMID: 2391684] |
| CCRF-CEM | IC50 |
8.9 μg/mL
Compound: LY-181984
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In vitro cytotoxicity against CCRF-CEM cells
In vitro cytotoxicity against CCRF-CEM cells
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[PMID: 9083492] |
| COLO 205 | IC50 |
83 μg/mL
Compound: 1
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Cytotoxic activity against human tumor COLO 205 cell line
Cytotoxic activity against human tumor COLO 205 cell line
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[PMID: 9216847] |
| HepG2 | IC50 |
>300 μg/mL
Compound: 1
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Cytotoxic activity against human tumor HepG2 cell line
Cytotoxic activity against human tumor HepG2 cell line
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[PMID: 9216847] |
| KB | IC50 |
72 μg/mL
Compound: 1
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Cytotoxic activity against human tumor KB cell line
Cytotoxic activity against human tumor KB cell line
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[PMID: 9216847] |
| TSGH 8302 | IC50 |
106 μg/mL
Compound: 1
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Cytotoxic activity against human tumor TSGH 8302 cell line
Cytotoxic activity against human tumor TSGH 8302 cell line
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[PMID: 9216847] |
Chemical Information
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CAS No. 3955-50-8
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Appearance Solid
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Masse moléculaire 324.78
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Formule C14H13ClN2O3S
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Color White to off-white
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SMILES
O=C(NS(=O)(C1=CC=C(C)C=C1)=O)NC2=CC=C(C=C2)Cl
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
In Vitro:
DMSO : 125 mg/mL (384.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureté et documentation
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Fiche technique (270 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Morré DJ, et al. A circulating form of NADH oxidase activity responsive to the antitumor sulfonylurea N-4-(methylphenylsulfonyl)-N'-(4-chlorophenyl)urea (LY181984) specific to sera from cancer patients. J Bioenerg Biomembr. 1997;29(3):281-289. [Content Brief]
[2]. Neubauer BL, et al. Inhibition of PAIII rat prostatic adenocarcinoma growth and metastasis by a new diarylsulfonylurea antitumor agent, LY181984. J Urol. 1992;147(2):500-504. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.0790 mL | 15.3950 mL | 30.7901 mL | 76.9752 mL |
| 5 mM | 0.6158 mL | 3.0790 mL | 6.1580 mL | 15.3950 mL | |
| 10 mM | 0.3079 mL | 1.5395 mL | 3.0790 mL | 7.6975 mL | |
| 15 mM | 0.2053 mL | 1.0263 mL | 2.0527 mL | 5.1317 mL | |
| 20 mM | 0.1540 mL | 0.7698 mL | 1.5395 mL | 3.8488 mL | |
| 25 mM | 0.1232 mL | 0.6158 mL | 1.2316 mL | 3.0790 mL | |
| 30 mM | 0.1026 mL | 0.5132 mL | 1.0263 mL | 2.5658 mL | |
| 40 mM | 0.0770 mL | 0.3849 mL | 0.7698 mL | 1.9244 mL | |
| 50 mM | 0.0616 mL | 0.3079 mL | 0.6158 mL | 1.5395 mL | |
| 60 mM | 0.0513 mL | 0.2566 mL | 0.5132 mL | 1.2829 mL | |
| 80 mM | 0.0385 mL | 0.1924 mL | 0.3849 mL | 0.9622 mL | |
| 100 mM | 0.0308 mL | 0.1540 mL | 0.3079 mL | 0.7698 mL |
LY 181984 Related Classifications
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