(S)-AMG-628
(S)-AMG-628 (Compound 16q) is the S-isomer of AMG-628 (HY-123374). (S)-AMG-628 is the orally active antagonist for TRPV1, that inhibits the Capsaicin (HY-10448)- and acid-induced Ca2+-influx with IC50 of 7 nM and 5 nM in CHO cell. (S)-AMG-628 ameliorates Capsaicin-induced rats flinching, and reverses the thermal hypersensitivity in CFA-(HY-153808) induced inflammatory pain models.
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- CAS No.: 862269-92-9
- Formule: C25H25FN6O2S
- Masse moléculaire:492.57
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | IC50 |
5 nM
Compound: 16q
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Inhibition of rat TRPV1 expressed in CHO cells assessed as acid-induced Ca2+ influx
Inhibition of rat TRPV1 expressed in CHO cells assessed as acid-induced Ca2+ influx
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[PMID: 17585751] |
| CHO | IC50 |
7 nM
Compound: 16q
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Inhibition of rat TRPV1 expressed in CHO cells assessed as capsaicin-induced Ca2+ influx
Inhibition of rat TRPV1 expressed in CHO cells assessed as capsaicin-induced Ca2+ influx
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[PMID: 17585751] |
Chemical Information
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CAS No. 862269-92-9
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Masse moléculaire 492.57
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Formule C25H25FN6O2S
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SMILES
CC(NC1=NC(C(S1)=CC=C2)=C2OC3=NC=NC(N4CCN(CC4)[C@H](C5=CC=C(C=C5)F)C)=C3)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(S)-AMG-628 Related Classifications
HY-169780 Related Classifications
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