Varacin
Varacin is a benzopentathiepin polysulfide derived from marine ascidians. It exerts cytotoxic, antibacterial, and antifungal activities by cleaving DNA through a redox pathway. Varacin can be used in research on cancer, fungal infections, and bacterial infections.
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- CAS No.: 134029-48-4
- Formule: C10H13NO2S5
- Masse moléculaire:339.52
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| HCT-116 | IC90 |
0.05 μg/mL
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Inhibition of human colon cancer HCT 116 cell growth measured via cytotoxicity assay.
Inhibition of human colon cancer HCT 116 cell growth measured via cytotoxicity assay.
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In Vitro
Varacin (compound 1) (2 μg per disk) exhibits potent antifungal activity against Candida albicans, producing an inhibition zone of 14 mm[1].
Varacin (2 µg per disk) exhibits antifungal activity against Candida albicans, producing a 14 mm inhibition zone at a paper disk loading of 2 µg[2].
Varacin (0.05 μg/mL) potently inhibits the growth of human colon cancer HCT 116 cells, with an IC90 of 0.05 μg/mL[1].
Varacin exhibits 1.5-fold greater cytotoxicity against CHO EM9 cells than against CHO BR1 cells, indicating its potential DNA-damaging activity[1].
Varacin exerts potent cytotoxic effects on human colon cancer HCT116 cells, with a IC90 of 0.05 µg/mL[2].
Varacin induces cytotoxicity in 8 different human cancer cell lines, with IC50 values ranging from 0.60 nM to 48.40 nM[2].
Varacin (0.1 μg) exhibits antibacterial activity against Bacillus subtilis in vitro, with an inhibition zone diameter of 20 mm at a concentration of 0.1 μg; meanwhile, it shows antifungal activity against Candida albicans, with an inhibition zone diameter of 20 mm at a concentration of 0.1 μg[3].
Varacin exhibits significant cytotoxic activity against the human colon cancer cell line HCT 116, along with notable antifungal activity; preliminary evidence indicates that DNA-damaging activity serves as its underlying cytotoxic mechanism of cytotoxicity[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 134029-48-4
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Masse moléculaire 339.52
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Formule C10H13NO2S5
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SMILES
O(C=1C=C(C=2SSSSSC2C1OC)CCN)C
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Structure Classification
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Initial Source
Lissoclinum vareau
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Varacin Related Classifications
HY-N21817 Related Classifications
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