XR11576
XR11576 (MLN576) is an orally active inhibitor of topoisomerase I and II. XR11576 shows cytotoxicity against human and murine tumor cell lines (IC50: 6-47 nM).
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- CAS No.: 346689-77-8
- Formule: C23H24N4O2
- Masse moléculaire:388.46
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| COR-L23 | IC50 |
10.1 nM
Compound: XR-11576
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Cytotoxicity measured using the COR-L23 parental (COR-L23/P) human non small cell lung carcinoma cell line
Cytotoxicity measured using the COR-L23 parental (COR-L23/P) human non small cell lung carcinoma cell line
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[PMID: 11806724] |
| COR-L23 | IC50 |
12.1 nM
Compound: XR-11576
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Cytotoxicity measured with the drug resistant human non small cell lung carcinoma cell line COR-L23 (COR-L23/R) which over expresses multidrug resistance associated with protein(MRP)
Cytotoxicity measured with the drug resistant human non small cell lung carcinoma cell line COR-L23 (COR-L23/R) which over expresses multidrug resistance associated with protein(MRP)
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[PMID: 11806724] |
| NCI-H69 | IC50 |
1.2 nM
Compound: 11
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Inhibitory activity against drug resistant H69/LX4 line overexpressing P-glycoprotein
Inhibitory activity against drug resistant H69/LX4 line overexpressing P-glycoprotein
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[PMID: 11806725] |
| NCI-H69 | IC50 |
23 nM
Compound: XR-11576
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Cytotoxicity measured using the H69 parental (H69/P) human small cell lung carcinoma cell line
Cytotoxicity measured using the H69 parental (H69/P) human small cell lung carcinoma cell line
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[PMID: 11806724] |
| NCI-H69 | IC50 |
23 nM
Compound: 11
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Inhibitory activity against parental human small cell lung carcinoma cell line (H69P)
Inhibitory activity against parental human small cell lung carcinoma cell line (H69P)
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[PMID: 11806725] |
| NCI-H69 | IC50 |
29 nM
Compound: XR-11576
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Cytotoxicity measured using the drug resistant, P-glycoprotein (Pgp) expressing human small cell lung carcinoma cell line H69/LX4
Cytotoxicity measured using the drug resistant, P-glycoprotein (Pgp) expressing human small cell lung carcinoma cell line H69/LX4
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[PMID: 11806724] |
| P388 | IC50 |
10 nM
Compound: 11
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Inhibitory activity against murine P388 leukemia (P388) cells.
Inhibitory activity against murine P388 leukemia (P388) cells.
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[PMID: 11806725] |
Chemical Information
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CAS No. 346689-77-8
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Masse moléculaire 388.46
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Formule C23H24N4O2
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SMILES
O=C(N[C@@H](CN(C)C)C)C1=C2C(N=C3C=CC4=C(C=CC=C4C3=N2)OC)=CC=C1
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Synonyms
MLN576
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Di Nicolantonio F, et al. Ex vivo characterization of XR11576 (MLN576) against ovarian cancer and other solid tumors. Anticancer Drugs. 2004 Oct;15(9):849-60. [Content Brief]
[2]. Mistry P, et al. In vitro and in vivo characterization of XR11576, a novel, orally active, dual inhibitor of topoisomerase I and II. Anticancer Drugs. 2002 Jan;13(1):15-28. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
XR11576 Related Classifications
HY-123143 Related Classifications
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