Carboxyrhodamine 110-PEG4-DBCO
Based on 1 Customer Validation
Carboxyrhodamine 110-PEG4-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Carboxyrhodamine 110-PEG4-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
For research use only. We do not sell to patients.
- Purity : 95.0%
- Formula: C50H49N5O10
- Molecular Weight:879.97
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All PROTAC Linkers Isoforms
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Biological Activity
Description
IC50 & Target
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PEGs |
In Vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Solid
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Molecular Weight 879.97
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Formula C50H49N5O10
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Color Purple to purplish red
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SMILES
[O-]C(C1=C(C2=C3C=CC(C=C3OC4=C2C=CC(N)=C4)=[NH2+])C=C(C(NCCOCCOCCOCCOCCC(NCCC(N5C6=C(C#CC7=C(C5)C=CC=C7)C=CC=C6)=O)=O)=O)C=C1)=O.[O-]C(C8=C(C(C9=C(O%10)C=C(N)C=C9)=C(C=C%11)C%10=CC%11=[NH2+])C=CC(C(NCCOCCOCCOCCOCCC(NCCC(N%12C%13=C(C#CC%14=C(C%12)C=CC=C%14)C=CC=C%13)=O)=O)=O)=C8)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro:
DMSO : 50 mg/mL (56.82 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.1364 mL | 5.6820 mL | 11.3640 mL | 28.4101 mL |
| 5 mM | 0.2273 mL | 1.1364 mL | 2.2728 mL | 5.6820 mL | |
| 10 mM | 0.1136 mL | 0.5682 mL | 1.1364 mL | 2.8410 mL | |
| 15 mM | 0.0758 mL | 0.3788 mL | 0.7576 mL | 1.8940 mL | |
| 20 mM | 0.0568 mL | 0.2841 mL | 0.5682 mL | 1.4205 mL | |
| 25 mM | 0.0455 mL | 0.2273 mL | 0.4546 mL | 1.1364 mL | |
| 30 mM | 0.0379 mL | 0.1894 mL | 0.3788 mL | 0.9470 mL | |
| 40 mM | 0.0284 mL | 0.1421 mL | 0.2841 mL | 0.7103 mL | |
| 50 mM | 0.0227 mL | 0.1136 mL | 0.2273 mL | 0.5682 mL |
Carboxyrhodamine 110-PEG4-DBCO Related Classifications
HY-140297 Related Classifications
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