Cardio-green butyl acetate
Cardio-green butyl acetate (CaGA) is a potent antifungal fungicide, with a K value of 3.20 × 104 M-1 for binding to Ergosterol in fungal cell membranes. Cardio-green butyl acetate binds specifically and non-covalently to Ergosterol in fungal cell membranes via hydrogen bonding and hydrophobic interactions, triggering local thinning of the cell membrane, disordered lipid arrangement, and content leakage. Cardio-green butyl acetate can be used in studies related to Candida albicans infections.
For research use only. We do not sell to patients.
- Formula: C55H69BrN2O6
- Molecular Weight:934.05
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
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Fungal Metabolite |
In Vitro
Cardio-green butyl acetate CaGA (2-16 µg/mL; 2 h) exhibits significant dose-dependent bactericidal activity against planktonic cells of Candida albicans SJ11[1].
Cardio-green butyl acetate (1-4 µg/mL; 5-60 min) induces intracellular protein and nucleic acid leakage, disrupts cell membrane integrity and lipid microdomains, causes cell surface wrinkling and shrinkage deformation, and leads to cell death in Candida albicans SJ11[1].
CaGA (100 µg/mL) specifically binds to ergosterol in a cell-free system, with a K value of 3.20 × 104 M-1[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Candida albicans SJ11
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Concentration:2 µg/mL, 4 µg/mL, 8 µg/mL, 16 µg/mL
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Incubation Time:2 h
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Result:
Dose-dependently reduced the viability of Candida albicans, reducing viable colonies by over 85% and 99% at 4 µg/mL and 8 µg/mL, respectively, and achieving complete inhibition at 16 µg/mL.
Chemical Information
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Molecular Weight 934.05
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Formula C55H69BrN2O6
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SMILES
[H]C(/C([H])=C(/C([H])=C(/C([H])=C(C1=[N+](C2=C(C1(C)C)C3=CC=CC=C3C=C2)CCCCOCCCCOC(C)=O)\[H])[H])[H])=C4N(C5=C(C/4(C)C)C(C=CC=C6)=C6C=C5)CCCCOCCCCOC(C)=O.[Br-]
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Synonyms
CaGA
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Cardio-green butyl acetate Related Classifications
HY-187676 Related Classifications
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