105591-35-3
Chemical Structure
Isochiisanoside
- CAS No.: 105591-35-3
- Formula:C48H76O20
- Molecular Weight:973.11
InChIKey: DEXFQQWSJHKUIA-VELBUPAJSA-N
SMILES: OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2[C@@H]([C@@H]([C@H]([C@@H](O2)C)O)O)O)O[C@H]1OC[C@H]([C@H]([C@@H]([C@H]3O)O)O)O[C@H]3OC([C@]45[C@@]([C@@H](CC5)C(C)=C)([H])[C@]6([H])[C@@](CC4)([C@]7([C@]([C@@]8([C@@](C(C)(O[C@@H]8CC(O)=O)C)([H])CC7)C)([H])[C@@H](C6)O)C)C)=O
Biological Activity: Isochiisanoside is a lupane-type triterpenoid triglycoside found in the leaves of Acanthopanax sessiliflorus. Isochiisanoside dose-dependently inhibits LPS (HY-D1056A1))-induced NO (IC50 = 64.25 μM) and PGE2 production in macrophages without obvious cytotoxicity. Isochiisanoside shows weak inhibitory activity against porcine pancreatic lipase. Isochiisanoside can be used in inflammation-related research[1][2][3].
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Isochiisanoside | Isochiisanoside is a lupane-type triterpenoid triglycoside found in the leaves of Acanthopanax sessiliflorus. Isochiisanoside dose-dependently inhibits LPS (HY-D1056A1))-induced NO (IC50 = 64.25 μM) and PGE2 production in macrophages without obvious cytotoxicity. Isochiisanoside shows weak inhibitory activity against porcine pancreatic lipase. Isochiisanoside can be used in inflammation-related research. | |||||||||||||||||||||
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References
- [1]. Yoshizumi K, et al. Lupane-type saponins from leaves of Acanthopanax sessiliflorus and their inhibitory activity on pancreatic lipase. Journal of agricultural and food chemistry. 2006 Jan 25;54(2):335-41. [Content Brief]
- [2]. KASAI R, et al. 3, 4-Seco-lupane type triterpene glycosyl esters from a Korean medicinal plant, Acanthopanax chiisanensis (Araliaceae)[J]. Chemical and pharmaceutical bulletin, 1986, 34(8): 3284-3289.
- [3]. Won JH, et al. Inhibition of lipopolysaccharide-induced expression of inducible nitric oxide and cyclooxygenase-2 by chiisanoside via suppression of nuclear factor-kappaB activation in RAW 264.7 macrophage cells. Biological & pharmaceutical bulletin. 2005 Oct;28(10):1919-24. [Content Brief]
