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Referencia número: HY-N21863

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Isochiisanoside

Isochiisanoside is a lupane-type triterpenoid triglycoside found in the leaves of Acanthopanax sessiliflorus. Isochiisanoside dose-dependently inhibits LPS-induced NO (IC₅₀=64.25 μM) and PGE₂ production in macrophages without obvious cytotoxicity. Isochiisanoside shows weak inhibitory activity against porcine pancreatic lipase. Isochiisanoside can be used in inflammation-related research.

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No. CAS: 105591-35-3
Fòrmula: C₄₈H₇₆O₂₀
Peso molecular:973.11

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Isochiisanoside Chemical Structure

No. CAS: 105591-35-3

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Actividad biológica

Descripciòn

Ver todos los productos específicos de isoformas NO Synthase :

In Vitro

Isochiisanoside (0.2-1 mg/mL; 20 min) weakly inhibits porcine pancreatic lipase activity in vitro, without showing a dose-dependent response^[1].
Isochiisanoside is isolated from the dried leaves of *Acanthopanax chiisanensis*, with a yield of 0.05%^[2].
Isochiisanoside (6.25-100 μM; 24 h) inhibits LPS-induced nitric oxide production in RAW 264.7 mouse macrophages in a dose-dependent manner, with an IC₅₀ of 64.25 μM, and shows no cytotoxicity^[3].
Isochiisanoside (25-100 μM; 1 h pre-incubation, followed by 24 h incubation with LPS (HY-D1056A1)) dose-dependently inhibits LPS-induced prostaglandin E₂ production in RAW 264.7 mouse macrophages without causing cytotoxicity^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ELISA Assay^[3]

Cell Line:

RAW 264.7 murine macrophage cell line
Concentration:

25, 50 and 100 μM
Incubation Time:

1 h pre-incubation; 24 h incubation with LPS (HY-D1056A1)
Result:

Inhibited LPS-induced PGE₂ production in a dose-dependent manner.
Did not affect cell viability at the concentrations used to inhibit PGE₂ production.

Chemical Information

No. CAS 105591-35-3
Peso molecular 973.11
Fòrmula C₄₈H₇₆O₂₀
SMILES

OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2[C@@H]([C@@H]([C@H]([C@@H](O2)C)O)O)O)O[C@H]1OC[C@H]([C@H]([C@@H]([C@H]3O)O)O)O[C@H]3OC([C@]45[C@@]([C@@H](CC5)C(C)=C)([H])[C@]6([H])[C@@](CC4)([C@]7([C@]([C@@]8([C@@](C(C)(O[C@@H]8CC(O)=O)C)([H])CC7)C)([H])[C@@H](C6)O)C)C)=O
Structure Classification
- Terpenoids
- Triterpenes
Initial Source
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Yoshizumi K, et al. Lupane-type saponins from leaves of Acanthopanax sessiliflorus and their inhibitory activity on pancreatic lipase. Journal of agricultural and food chemistry. 2006 Jan 25;54(2):335-41.

[2]. KASAI R, et al. 3, 4-Seco-lupane type triterpene glycosyl esters from a Korean medicinal plant, Acanthopanax chiisanensis (Araliaceae)[J]. Chemical and pharmaceutical bulletin, 1986, 34(8): 3284-3289.

[3]. Won JH, et al. Inhibition of lipopolysaccharide-induced expression of inducible nitric oxide and cyclooxygenase-2 by chiisanoside via suppression of nuclear factor-kappaB activation in RAW 264.7 macrophage cells. Biological & pharmaceutical bulletin. 2005 Oct;28(10):1919-24.

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Isochiisanoside

Ver todos los productos específicos de isoformas NO Synthase