Isochiisanoside
Isochiisanoside is a lupane-type triterpenoid triglycoside found in the leaves of Acanthopanax sessiliflorus. Isochiisanoside dose-dependently inhibits LPS (HY-D1056A1))-induced NO (IC50 = 64.25 μM) and PGE2 production in macrophages without obvious cytotoxicity. Isochiisanoside shows weak inhibitory activity against porcine pancreatic lipase. Isochiisanoside can be used in inflammation-related research.
For research use only. We do not sell to patients.
- CAS No.: 105591-35-3
- Formula: C48H76O20
- Molecular Weight:973.11
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Isochiisanoside (0.2-1 mg/mL; 20 min) weakly inhibits porcine pancreatic lipase activity in vitro, without showing a dose-dependent response[1].
Isochiisanoside is isolated from the dried leaves of Acanthopanax chiisanensis, with a yield of 0.05%[2].
Isochiisanoside (6.25-100 μM; 24 h) inhibits LPS-induced nitric oxide production in RAW 264.7 mouse macrophages in a dose-dependent manner, with an IC50 of 64.25 μM, and shows no cytotoxicity[3].
Isochiisanoside (25-100 μM; 1 h pre-incubation, followed by 24 h incubation with LPS (HY-D1056A1)) dose-dependently inhibits LPS-induced prostaglandin E2 production in RAW 264.7 mouse macrophages without causing cytotoxicity[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RAW 264.7 murine macrophage cell line
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Concentration:25, 50 and 100 μM
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Incubation Time:1 h pre-incubation; 24 h incubation with LPS (HY-D1056A1)
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Result:Inhibited LPS-induced PGE2 production in a dose-dependent manner.
Did not affect cell viability at the concentrations used to inhibit PGE2 production.
Chemical Information
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CAS No. 105591-35-3
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Molecular Weight 973.11
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Formula C48H76O20
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SMILES
OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2[C@@H]([C@@H]([C@H]([C@@H](O2)C)O)O)O)O[C@H]1OC[C@H]([C@H]([C@@H]([C@H]3O)O)O)O[C@H]3OC([C@]45[C@@]([C@@H](CC5)C(C)=C)([H])[C@]6([H])[C@@](CC4)([C@]7([C@]([C@@]8([C@@](C(C)(O[C@@H]8CC(O)=O)C)([H])CC7)C)([H])[C@@H](C6)O)C)C)=O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Yoshizumi K, et al. Lupane-type saponins from leaves of Acanthopanax sessiliflorus and their inhibitory activity on pancreatic lipase. Journal of agricultural and food chemistry. 2006 Jan 25;54(2):335-41. [Content Brief]
[3]. Won JH, et al. Inhibition of lipopolysaccharide-induced expression of inducible nitric oxide and cyclooxygenase-2 by chiisanoside via suppression of nuclear factor-kappaB activation in RAW 264.7 macrophage cells. Biological & pharmaceutical bulletin. 2005 Oct;28(10):1919-24. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Isochiisanoside Related Classifications
HY-N21863 Related Classifications
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