Lupane-type saponins from leaves of Acanthopanax sessiliflorus and their inhibitory activity on pancreatic lipase

  • J Agric Food Chem. 2006 Jan 25;54(2):335-41. doi: 10.1021/jf052047f.
Kazuma Yoshizumi  1 ,  Kaoru Hirano ,  Hidehiro Ando ,  Yasuaki Hirai ,  Yoshiteru Ida ,  Tomoko Tsuji ,  Tamotsu Tanaka ,  Kiyoshi Satouchi ,  Junji Terao
Affiliations
  • 1. Central Research Laboratory, Fancl Corporation, 12-13 Kamishinano, Totsuka-ku, Yokohama, Kanagawa 244-0806, Japan.
PMID: 16417288 DOI: 10.1021/jf052047f
Abstract

Three known saponins, chiisanoside, 11-deoxyisochiisanoside, and isochiisanoside, and one novel saponin, 3,4-seco-4(23),20(29)-lupadiene-3,28-dioic acid 28-O-alpha-l-rhamnopyranosyl (1-->4)-beta-d-glucopyranosyl (1-->6)-beta-d-glucopyranoside, referred to as sessiloside, were isolated from a hot water Extract of Acanthopanax sessiliflorus leaves. All of these saponins were lupane-type triterpene triglycosides, and their concentrations were 4.1, 1.0, 0.5, and 0.4% (w/w) of the total Extract, respectively. Sessiloside and chiisanoside inhibited pancreatic Lipase activity in vitro, and addition of the saponin-rich fraction to a high-fat diet suppressed the body weight gain of mice. The possibility of application of the lupane-type saponins from A. sessiliflorus leaves to the treatment of Obesity is discussed.

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