1174559-81-9
Chemical Structure
VHPKQHR
- CAS No.: 1174559-81-9
- Formula:C39H64N16O9
- Molecular Weight:901.03
InChIKey: NFKHHKFJYSLWFL-IRQHXVELSA-N
SMILES: CC(C)[C@H](N)C(N[C@@H](CC1=CN=CN1)C(N2[C@@H](CCC2)C(N[C@@H](CCCCN)C(N[C@@H](CCC(N)=O)C(N[C@H](C(N[C@H](C(O)=O)CCCNC(N)=N)=O)CC3=CN=CN3)=O)=O)=O)=O)=O
Biological Activity: VHPKQHR is a peptide-based delivery enhancer that binds to VCAM-1. VHPKQHR enables intracellular internalization of relevant nanomaterials and facilitates the targeted delivery of miRNA inhibitors to inflamed endothelial cells and endothelial cells activated by disturbed flow. When conjugated with magnetic mesoporous silica nanoparticles, VHPKQHR achieves targeted accumulation at atherosclerotic plaque sites. When displayed on the surface of polyelectrolyte complex micelles, VHPKQHR enhances the relevant effects of anti-miR-92a in Apoe-/- mice. When conjugated with ultrasmall superparamagnetic iron oxide nanoparticles, VHPKQHR forms a contrast agent for T1-weighted magnetic resonance imaging. VHPKQHR can be used in research related to atherosclerosis, stenosis and rheumatoid arthritis[1][2][3].
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VHPKQHR | VHPKQHR is a peptide-based delivery enhancer that binds to VCAM-1. VHPKQHR enables intracellular internalization of relevant nanomaterials and facilitates the targeted delivery of miRNA inhibitors to inflamed endothelial cells and endothelial cells activated by disturbed flow. When conjugated with magnetic mesoporous silica nanoparticles, VHPKQHR achieves targeted accumulation at atherosclerotic plaque sites. When displayed on the surface of polyelectrolyte complex micelles, VHPKQHR enhances the relevant effects of anti-miR-92a in Apoe-/- mice. When conjugated with ultrasmall superparamagnetic iron oxide nanoparticles, VHPKQHR forms a contrast agent for T1-weighted magnetic resonance imaging. VHPKQHR can be used in research related to atherosclerosis, stenosis and rheumatoid arthritis. | |||||||||||||||||||||
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- [1]. Zhou Z, et al. Targeted polyelectrolyte complex micelles treat vascular complications in vivo. Proceedings of the National Academy of Sciences of the United States of America. 2021 Dec 14;118(50):e2114842118. [Content Brief]
- [2]. Zhang C, et al. VHPKQHR Peptide Modified Ultrasmall Paramagnetic Iron Oxide Nanoparticles Targeting Rheumatoid Arthritis for T1-Weighted Magnetic Resonance Imaging. Front Bioeng Biotechnol. 2022 Feb 28;10:821256. [Content Brief]
- [3]. Xu W, et al. VHPKQHR peptide modified magnetic mesoporous nanoparticles for MRI detection of atherosclerosis lesions. Artificial cells, nanomedicine, and biotechnology. 2019 Dec;47(1):2440-2448. [Content Brief]
Keywords
