1219794-90-7
1219794-90-7
Chemical Structure
Valdecoxib-d3
Synonym(s): SC 65872-d3
- CAS No.: 1219794-90-7
- Formula:C16H11D3N2O3S
- Molecular Weight:317.38
IUPAC Name: 4-(5-(methyl-d3)-3-phenylisoxazol-4-yl)benzenesulfonamide
InChIKey: LNPDTQAFDNKSHK-FIBGUPNXSA-N
SMILES: NS(C(C=C1)=CC=C1C(C(C2=CC=CC=C2)=NO3)=C3C([2H])([2H])[2H])(=O)=O
Biological Activity: Valdecoxib-d3 is the deuterium labeled Valdecoxib. Valdecoxib is a highly potent and selective inhibitor of COX-2, with IC50s of 5 nM and 140 μM for COX-2 and COX-1, respeceively. Valdecoxib can be used in the research of arthritis and pain[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Valdecoxib-d3 | Valdecoxib-d3 is the deuterium labeled Valdecoxib. Valdecoxib is a highly potent and selective inhibitor of COX-2, with IC50s of 5 nM and 140 μM for COX-2 and COX-1, respeceively. Valdecoxib can be used in the research of arthritis and pain. | |||||||||||||||||||||
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Valdecoxib (Standard) | ≥98% | Valdecoxib (Standard) is the analytical standard of Valdecoxib. This product is intended for research and analytical applications. Valdecoxib is a highly potent and selective inhibitor of COX-2, with IC50s of 5 nM and 140 μM for COX-2 and COX-1, respeceively. Valdecoxib can be used in the research of arthritis and pain. | ||||||||||||||||||||
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Valdecoxib-13C2,15N | Valdecoxib-13C2,15N (SC 65872-13C2,15N) is the 13C- and 15N-labeled Valdecoxib (HY-15762). Valdecoxib is a highly potent and selective inhibitor of COX-2, with IC50s of 5 nM and 140 μM for COX-2 and COX-1, respeceively. Valdecoxib can be used in the research of arthritis and pain. | |||||||||||||||||||||
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Valdecoxib | 99.89% | Valdecoxib is a highly potent and selective inhibitor of COX-2, with IC50s of 5 nM and 140 μM for COX-2 and COX-1, respeceively. Valdecoxib can be used in the research of arthritis and pain. | ||||||||||||||||||||
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References
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
- [2]. Talley JJ, et al. 4-[5-Methyl-3-phenylisoxazol-4-yl]- benzenesulfonamide, valdecoxib: a potent and selective inhibitor of COX-2. J Med Chem. 2000 Mar 9;43(5):775-7. [Content Brief]
