136826-50-1
![1-Dehydro-[10]-gingerdione Chemical Structure](http://file.medchemexpress.cn/product_pic/hy-n10768.gif "1-Dehydro-[10]-gingerdione Chemical Structure")
Chemical Structure
1-Dehydro-[10]-gingerdione
- CAS. Nr.: 136826-50-1
- Formula:C21H30O4
- Molecular Weight:346.46
IUPAC Name: (E)-1-(4-hydroxy-3-methoxyphenyl)tetradec-1-ene-3,5-dione
InChIKey: QJDGTTCAEQPSJA-ACCUITESSA-N
SMILES: O=C(CC(CCCCCCCCC)=O)/C=C/C1=CC=C(C(OC)=C1)O
Biological Activity: 1-Dehydro-[10]-gingerdione directly inhibits IKKβ activity by targeting the activation loop of IKKβ, thus disrupting IKKβ-catalysed IκBα phosphorylation in macrophages stimulated with agonists. 1-Dehydro-[10]-gingerdione inhibits LPS (HY-D1056)-induced NF-κB transcriptional activity. 1-Dehydro-[10]-gingerdione has the potential for NF-κB-associated inflammation and autoimmune disorders research[1].
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1-Dehydro-[10]-gingerdione | 1-Dehydro--gingerdione directly inhibits IKKβ activity by targeting the activation loop of IKKβ, thus disrupting IKKβ-catalysed IκBα phosphorylation in macrophages stimulated with agonists. 1-Dehydro--gingerdione inhibits LPS (HY-D1056)-induced NF-κB transcriptional activity. 1-Dehydro--gingerdione has the potential for NF-κB-associated inflammation and autoimmune disorders research. | |||||||||||||||||||||
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Keywords
