1. NF-κB
  2. IKK
    NF-κB
  3. 1-Dehydro-[10]-gingerdione

1-Dehydro-[10]-gingerdione 

Cat. No.: HY-N10768
Handling Instructions

1-Dehydro-[10]-gingerdione directly inhibits IKKβ activity by targeting the activation loop of IKKβ, thus disrupting IKKβ-catalysed IκBα phosphorylation in macrophages stimulated with agonists. 1-Dehydro-[10]-gingerdione inhibits LPS (HY-D1056)-induced NF-κB transcriptional activity. 1-Dehydro-[10]-gingerdione has the potential for NF-κB-associated inflammation and autoimmune disorders research.

For research use only. We do not sell to patients.

1-Dehydro-[10]-gingerdione Chemical Structure

1-Dehydro-[10]-gingerdione Chemical Structure

CAS No. : 136826-50-1

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Description

1-Dehydro-[10]-gingerdione directly inhibits IKKβ activity by targeting the activation loop of IKKβ, thus disrupting IKKβ-catalysed IκBα phosphorylation in macrophages stimulated with agonists. 1-Dehydro-[10]-gingerdione inhibits LPS (HY-D1056)-induced NF-κB transcriptional activity. 1-Dehydro-[10]-gingerdione has the potential for NF-κB-associated inflammation and autoimmune disorders research[1].

Molecular Weight

346.46

Formula

C21H30O4

CAS No.
SMILES

O=C(CC(CCCCCCCCC)=O)/C=C/C1=CC=C(C(OC)=C1)O

Structure Classification
Source
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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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1-Dehydro-[10]-gingerdione
Cat. No.:
HY-N10768
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