1375466-18-4
1375466-18-4
Chemical Structure
ACY-775
- CAS No.: 1375466-18-4
- Formula:C17H19FN4O2
- Molecular Weight:330.36
IUPAC Name: 2-((1-(3-fluorophenyl)cyclohexyl)amino)-N-hydroxypyrimidine-5-carboxamide
InChIKey: IYBURCQQEUNLDL-UHFFFAOYSA-N
SMILES: O=C(NO)C(C=N1)=CN=C1NC2(CCCCC2)C3=CC=CC(F)=C3
Biological Activity: ACY-775 is a potent and selective inhibitor of the of histone deacetylase 6 (HDAC6) with an IC50 of 7.5 nM[1][2]. ACY775 also inhibits metallo-β-lactamase domain-containing protein 2 (MBLAC2)[3].
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ACY-775 | 99.71% | ACY-775 is a potent and selective inhibitor of the of histone deacetylase 6 (HDAC6) with an IC50 of 7.5 nM. ACY775 also inhibits metallo-β-lactamase domain-containing protein 2 (MBLAC2). | ||||||||||||||||||||
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References
- [1]. Veronick Benoy, et al. Development of Improved HDAC6 Inhibitors as Pharmacological Therapy for Axonal Charcot-Marie-Tooth Disease. Neurotherapeutics. 2017 Apr; 14(2): 417-428. [Content Brief]
- [2]. Jeanine Jochems et al. Antidepressant-Like Properties of Novel HDAC6-Selective Inhibitors with Improved Brain Bioavailability. Neuropsychopharmacology. 2014 Jan; 39(2): 389-400. [Content Brief]
- [3]. Severin Lechner, et al. Target deconvolution of HDAC pharmacopoeia reveals MBLAC2 as common off-target. Nat Chem Biol. 2022 Apr 28. [Content Brief]
Keywords
