139256-06-7
Chemical Structure
7-Hydroxy-3-(3-methoxyphenyl)-4H-chromen-4-one
- CAS No.: 139256-06-7
- Formula:C16H12O4
- Molecular Weight:268.26
IUPAC Name: 5-amino-2-(2-methoxyethyl)-1,2,4-thiadiazol-3(2H)-one
InChIKey: SVIVXHGAPCFWCS-UHFFFAOYSA-N
SMILES: COC1=CC=CC(=C1)C2=COC3=C(C2=O)C=CC(=C3)O
Biological Activity: 7-Hydroxy-3-(3-methoxyphenyl)-4H-chromen-4-one is a dual agonist of PPARα and PPARγ, with an EC50 of 23.10 μM for human PPARα and an EC50 of 22.29 μM for human PPARγ. 7-Hydroxy-3-(3-methoxyphenyl)-4H-chromen-4-one regulates the expression of lipid metabolism-related genes via PPARα, and modulates the expression of genes associated with glucose homeostasis and adipogenesis via PPARγ. 7-Hydroxy-3-(3-methoxyphenyl)-4H-chromen-4-one can be used in the research of type 2 diabetes and metabolic syndrome[1].
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7-Hydroxy-3-(3-methoxyphenyl)-4H-chromen-4-one | 7-Hydroxy-3-(3-methoxyphenyl)-4H-chromen-4-one is a dual agonist of PPARα and PPARγ, with an EC50 of 23.10 μM for human PPARα and an EC50 of 22.29 μM for human PPARγ. 7-Hydroxy-3-(3-methoxyphenyl)-4H-chromen-4-one regulates the expression of lipid metabolism-related genes via PPARα, and modulates the expression of genes associated with glucose homeostasis and adipogenesis via PPARγ. 7-Hydroxy-3-(3-methoxyphenyl)-4H-chromen-4-one can be used in the research of type 2 diabetes and metabolic syndrome. | |||||||||||||||||||||
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