1421610-21-0
1421610-21-0
Chemical Structure
IQ-1S
- CAS 番号: 1421610-21-0
- Formula:C15H8N3NaO
- Molecular Weight:269.23
IUPAC Name: (E)-11H-indeno[1,2-b]quinoxalin-11-one oxime, sodium salt
InChIKey: JBNHEGDICQSOLR-LSJACRKWSA-N
SMILES: [Na]O/N=C1C2=C(C3=NC4=CC=CC=C4N=C3\1)C=CC=C2
Biological Activity: IQ-1S is a prospective inhibitor of NF-κB/activating protein 1 (AP-1) activity with an IC50 of 1.8 μM. IQ-1 has binding affinity (Kd values) in the nanomolar range for all three JNKs with Kds of 87 nM, 360 nM, and 390 nM for JNK3, JNK2, and JNK1, respectively.
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IQ-1S | IQ-1S is a prospective inhibitor of NF-κB/activating protein 1 (AP-1) activity with an IC50 of 1.8 μM. IQ-1 has binding affinity (Kd values) in the nanomolar range for all three JNKs with Kds of 87 nM, 360 nM, and 390 nM for JNK3, JNK2, and JNK1, respectively. | |||||||||||||||||||||
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Keywords
