IQ-1S
Based on 1 publication(s) in Google Scholar
IQ-1S is a prospective inhibitor of NF-κB/activating protein 1 (AP-1) activity with an IC50 of 1.8 μM. IQ-1 has binding affinity (Kd values) in the nanomolar range for all three JNKs with Kds of 87 nM, 360 nM, and 390 nM for JNK3, JNK2, and JNK1, respectively.
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- CAS. Nr.: 1421610-21-0
- Formel: C15H8N3NaO
- Molecular Weight:269.23
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Publications Citing Use of MedChemExpress (MCE) IQ-1S
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Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
JNK3 87 nM (Kd) |
JNK2 360 nM (Kd) |
JNK1 390 nM (Kd) |
PI3Kγ 1.2 μM (Kd) |
CK1δ 1.4 μM (Kd) |
MKNK2 1.8 μM (Kd) |
In Vitro
IQ-1S (The sodium salt of IQ-1) is a potent, noncytotoxic inhibitor of pro-inflammatory cytokine [IL-1α, IL-1β, IL-6, IL-10, TNF-α, interferon-γ, and GM-CSF)] and nitric oxide production by human and murine monocyte/macrophages. The effect of IQ-1 is evaluated on LPS-induced cytokine production in human PBMCs. Among the 12 cytokines analyzed, LPS (200 ng/mL) consistently induces five (IL-1α, IL-1β, IL-6, IL-10, and TNF-α) in PBMCs compared with DMSO-treated control cells. Production of all of these cytokines is significantly inhibited by 20 μM IQ-1. Among them, TNF-α production is inhibited completely by IQ-1 (>99%), the levels of IL-1α, IL-1β, and IL-10 are decreased by 85%, and IL-6 production is decreased by 33%. IQ-1S inhibits LPS-induced TNF-α and IL-6 production in MonoMac-6 cells with IC50 values of 0.25 and 0.61 μM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 1421610-21-0
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Molecular Weight 269.23
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Formel C15H8N3NaO
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SMILES
[Na]O/N=C1C2=C(C3=NC4=CC=CC=C4N=C3\1)C=CC=C2
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
IQ-1S Related Classifications
HY-100233A Related Classifications
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