1782109-09-4
1782109-09-4
Chemical Structure
RKI-1447 dihydrochloride
- CAS No.: 1782109-09-4
- Formula:C16H16Cl2N4O2S
- Molecular Weight:399.29
IUPAC Name: 1-(3-hydroxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea dihydrochloride
InChIKey: GBXLRAPHQIRDNS-UHFFFAOYSA-N
SMILES: O=C(NC1=NC(C2=CC=NC=C2)=CS1)NCC3=CC=CC(O)=C3.[H]Cl.[H]Cl
Biological Activity: RKI 1447 dihydrochloride is a potent and selective ROCK inhibitor with IC50s of 14.5 and 6.2 nM for ROCK1 and ROCK2, respectively[1]. RKI 1447 dihydrochloride suppresses colorectal carcinoma cell growth and promotes apoptosis[2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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RKI-1447 dihydrochloride | 99.94% | RKI 1447 dihydrochloride is a potent and selective ROCK inhibitor with IC50s of 14.5 and 6.2 nM for ROCK1 and ROCK2, respectively. RKI 1447 dihydrochloride suppresses colorectal carcinoma cell growth and promotes apoptosis. | ||||||||||||||||||||
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References
- [1]. Ronil A Patel, et al. RKI-1447 Is a Potent Inhibitor of the Rho-associated ROCK Kinases With Anti-Invasive and Antitumor Activities in Breast Cancer. Cancer Res. 2012 Oct 1;72(19):5025-34. [Content Brief]
- [2]. Liyi Li, et al. RKI-1447 Suppresses Colorectal Carcinoma Cell Growth via Disrupting Cellular Bioenergetics and Mitochondrial Dynamics. J Cell Physiol. 2020 Jan;235(1):254-266. [Content Brief]
Keywords
