2181-75-1
Chemical Structure
Indicaxanthin
- CAS No.: 2181-75-1
- Formula:C14H16N2O6
- Molecular Weight:308.29
IUPAC Name: (S)-4-((E)-2-((S)-2-carboxypyrrolidin-1-yl)vinyl)-2,3-dihydropyridine-2,6-dicarboxylic acid
InChIKey: CCXPAUKIWRMEET-UTSBZEJYSA-N
SMILES: OC(C1=N[C@@H](CC(/C=C/N2CCC[C@H]2C(O)=O)=C1)C(O)=O)=O
Biological Activity: Indicaxanthin is an orally available, blood-brain barrier-permeable bioavailable betalain pigment (Betalain Pigment) found in the fruits of Opuntia ficus-indica. Indicaxanthin exhibits antioxidant, anti-inflammatory, antiproliferative and neuromodulatory activities. Indicaxanthin modulates glutamatergic neurotransmission and inhibits PGE2, TNF-α, IL-1β, iNOS, COX-2 and NF-κB-related inflammatory responses. Indicaxanthin can be used in studies of melanoma, colorectal cancer, acute inflammation, obesity-associated insulin resistance and glutamatergic neuromodulation[1][2][3][4][5][6][7][8].
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Indicaxanthin | Indicaxanthin is an orally available, blood-brain barrier-permeable bioavailable betalain pigment (Betalain Pigment) found in the fruits of Opuntia ficus-indica. Indicaxanthin exhibits antioxidant, anti-inflammatory, antiproliferative and neuromodulatory activities. Indicaxanthin modulates glutamatergic neurotransmission and inhibits PGE2, TNF-α, IL-1β, iNOS, COX-2 and NF-κB-related inflammatory responses. Indicaxanthin can be used in studies of melanoma, colorectal cancer, acute inflammation, obesity-associated insulin resistance and glutamatergic neuromodulation. | |||||||||||||||||||||
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- [1]. Butera D, et al. Antioxidant activities of sicilian prickly pear (Opuntia ficus indica) fruit extracts and reducing properties of its betalains: betanin and indicaxanthin. Journal of agricultural and food chemistry. 2002 Nov 06;50(23):6895-901. [Content Brief]
- [2]. Ragusa MA, et al. Indicaxanthin Induces Autophagy in Intestinal Epithelial Cancer Cells by Epigenetic Mechanisms Involving DNA Methylation. Nutrients. 2023 Aug 07;15(15):3495. [Content Brief]
- [3]. Restivo I, et al. Indicaxanthin prevents eryptosis induced by cigarette smoke extract by interfering with active Fas-mediated signaling. BioFactors (Oxford, England). 2024;50(5):997-1008. [Content Brief]
- [4]. Allegra M, et al. Indicaxanthin from Opuntia ficus indica (L. Mill) impairs melanoma cell proliferation, invasiveness and tumor progression. Phytomedicine. 2018. [Content Brief]
- [5]. Terzo S, et al. Indicaxanthin from Opuntia ficus-indica Fruit Ameliorates Glucose Dysmetabolism and Counteracts Insulin Resistance in High-Fat-Diet-Fed Mice. Antioxidants. 2022;11:80. [Content Brief]
- [6]. Ragusa MA, et al. Indicaxanthin Induces Autophagy in Intestinal Epithelial Cancer Cells by Epigenetic Mechanisms Involving DNA Methylation. Nutrients. 2023;15:3495. [Content Brief]
- [7]. Allegra M, et al. Indicaxanthin from Opuntia Ficus Indica (L. Mill) impairs melanoma cell proliferation, invasiveness, and tumor progression. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2018 Nov 15;50:19-24. [Content Brief]
- [8]. Restivo I, et al. Indicaxanthin prevents eryptosis induced by cigarette smoke extract by interfering with active Fas-mediated signaling. [Content Brief]
Keywords
