2241294-16-4
2241294-16-4
Chemical Structure
Desmethyl-QCA276-C3-alkyne
- CAS No.: 2241294-16-4
- Formula:C26H23N5OS
- Molecular Weight:453.56
InChIKey: FRQQREOLCKVLGM-UHFFFAOYSA-N
SMILES: C#CCCCN1N=CC(C#CC(S2)=C(CC3=CC=CC=C3)C(COC4)=C2N5C4=NN=C5C)=C1
Biological Activity: Desmethyl-QCA276-C3-alkyne (Compound 71) is a Target Protein Ligand-Linker Conjugate, composed of the BET ligand Desmethyl-QCA276 (HY-44103) and the PROTAC linker (HY-W035972). Desmethyl-QCA276-C3-alkyne is applicable for the synthesis of the PROTAC QCA570 (HY-112609). Desmethyl-QCA276-C3-alkyne is used in cancer research[1].
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Desmethyl-QCA276-C3-alkyne | Desmethyl-QCA276-C3-alkyne (Compound 71) is a Target Protein Ligand-Linker Conjugate, composed of the BET ligand Desmethyl-QCA276 (HY-44103) and the PROTAC linker (HY-W035972). Desmethyl-QCA276-C3-alkyne is applicable for the synthesis of the PROTAC QCA570 (HY-112609). Desmethyl-QCA276-C3-alkyne is used in cancer research. | |||||||||||||||||||||
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References
- [1]. Qin C, et al. Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor Regression. Journal of medicinal chemistry. 2018 Aug 09;61(15):6685-6704. [Content Brief]
Keywords
