Desmethyl-QCA276-C3-alkyne
Desmethyl-QCA276-C3-alkyne (Compound 71) is a Target Protein Ligand-Linker Conjugate, composed of the BET ligand Desmethyl-QCA276 (HY-44103) and the PROTAC linker (HY-W035972). Desmethyl-QCA276-C3-alkyne is applicable for the synthesis of the PROTAC QCA570 (HY-112609). Desmethyl-QCA276-C3-alkyne is used in cancer research.
For research use only. We do not sell to patients.
- CAS No.: 2241294-16-4
- Formula: C26H23N5OS
- Molecular Weight:453.56
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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BET |
Chemical Information
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CAS No. 2241294-16-4
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Molecular Weight 453.56
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Formula C26H23N5OS
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SMILES
C#CCCCN1N=CC(C#CC(S2)=C(CC3=CC=CC=C3)C(COC4)=C2N5C4=NN=C5C)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Qin C, et al. Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor Regression. Journal of medicinal chemistry. 2018 Aug 09;61(15):6685-6704. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Desmethyl-QCA276-C3-alkyne Related Classifications
HY-184537 Related Classifications
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