2412273-73-3
Chemical Structure
PROTAC α-synuclein degrader 1
- CAS No.: 2412273-73-3
- Formula:C43H52N6O7S2
- Molecular Weight:829.04
IUPAC Name: (2S,4R)-1-((S)-3,3-dimethyl-2-(2-(2-(2-((2-(4-(methylamino)phenyl)benzo[d]thiazol-6-yl)oxy)ethoxy)ethoxy)acetamido)butanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide
InChIKey: HEFCGIGBHUUZJR-GNAZCYGUSA-N
SMILES: O=C(N1[C@@H](C[C@H](C1)O)C(N[C@H](C2=CC=C(C3=C(N=CS3)C)C=C2)C)=O)[C@H](C(C)(C)C)NC(COCCOCCOC4=CC=C(N=C(C5=CC=C(C=C5)NC)S6)C6=C4)=O
Biological Activity: PROTAC α-synuclein degrader 1 is a α-synuclein PROTAC degrader that can recruit VHL. PROTAC α-synuclein degrader 1 induces ubiquitination and degradation of α-synuclein, and is applicable to researches on Parkinson's disease, Alzheimer's disease, dementia with Lewy bodies, multiple system atrophy, etc.[1][2]
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PROTAC α-synuclein degrader 1 | PROTAC α-synuclein degrader 1 is a α-synuclein PROTAC degrader that can recruit VHL. PROTAC α-synuclein degrader 1 induces ubiquitination and degradation of α-synuclein, and is applicable to researches on Parkinson's disease, Alzheimer's disease, dementia with Lewy bodies, multiple system atrophy, etc. | |||||||||||||||||||||
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References
- [1]. Crew, A.P., et al. Proteolysis targeting chimeric (PROTAC) compound with E3 ubiquitin ligase binding activity and targeting alpha-synuclein protein for treating neurovegetative diseases. WO2020041331A1. WIPO. 27.02.2020.
- [2]. Kargbo RB. PROTAC Compounds Targeting α-Synuclein Protein for Treating Neurogenerative Disorders: Alzheimer's and Parkinson's Diseases. ACS Med Chem Lett. 2020 Apr 28;11(6):1086-1087.
