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Cat. No.: HY-135999

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PROTAC α-synuclein degrader 1

PROTAC α-synuclein degrader 1 is a α-synuclein PROTAC degrader that can recruit VHL. PROTAC α-synuclein degrader 1 induces ubiquitination and degradation of α-synuclein, and is applicable to researches on Parkinson's disease, Alzheimer's disease, dementia with Lewy bodies, multiple system atrophy, etc.
(Pink: α-synuclein ligand (HY-W278021); Blue: VHL ligand (HY-112078); Black: linker (HY-140497)).

For research use only. We do not sell to patients.

CAS No.: 2412273-73-3
Formula: C₄₃H₅₂N₆O₇S₂
Molecular Weight:829.04

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PROTAC α-synuclein degrader 1 Chemical Structure

CAS No.: 2412273-73-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

PROTAC α-synuclein degrader 1 is a α-synuclein PROTAC degrader that can recruit VHL. PROTAC α-synuclein degrader 1 induces ubiquitination and degradation of α-synuclein, and is applicable to researches on Parkinson's disease, Alzheimer's disease, dementia with Lewy bodies, multiple system atrophy, etc.^[1]^[2] (Pink: α-synuclein ligand (HY-W278021); Blue: VHL ligand (HY-112078); Black: linker (HY-140497)).

IC₅₀ & Target

^[2]

α-synuclein

All PROTACs Isoforms :

All α-synuclein Isoforms :

In Vitro

PROTAC α-synuclein degrader 1 (compound 1) (1 μM) potently induces α-synuclein degradation in HEK293 TREX α-syn^A53T cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2412273-73-3
Molecular Weight 829.04
Formula C₄₃H₅₂N₆O₇S₂
SMILES

O=C(N1[C@@H](C[C@H](C1)O)C(N[C@H](C2=CC=C(C3=C(N=CS3)C)C=C2)C)=O)[C@H](C(C)(C)C)NC(COCCOCCOC4=CC=C(N=C(C5=CC=C(C=C5)NC)S6)C6=C4)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Crew, A.P., et al. Proteolysis targeting chimeric (PROTAC) compound with E3 ubiquitin ligase binding activity and targeting alpha-synuclein protein for treating neurovegetative diseases. WO2020041331A1. WIPO. 27.02.2020.

[2]. Kargbo RB. PROTAC Compounds Targeting α-Synuclein Protein for Treating Neurogenerative Disorders: Alzheimer's and Parkinson's Diseases. ACS Med Chem Lett. 2020 Apr 28;11(6):1086-1087.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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